1. Stem Cell/Wnt
  2. Smo
  3. AZD7254

AZD7254 

Cat. No.: HY-147744
Handling Instructions

AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC50 of 1.0 nM against sonic Hh protein (shh).

For research use only. We do not sell to patients.

AZD7254 Chemical Structure

AZD7254 Chemical Structure

CAS No. : 1126366-28-6

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Description

AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC50 of 1.0 nM against sonic Hh protein (shh)[1].

In Vivo

AZD7254 (40 mg/kg; p.o.; twice daily for 10 days) exhibits 42% tumor growth inhibition in an HT29-MEF (murine embryonic fibroblast) co-implant xenograft model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

398.46

Formula

C24H22N4O2

CAS No.
SMILES

O=C(NC1=CC(C2=NC=CN2)=C(C)C=C1C)C3=CC=C(OCC4=NC=CC=C4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
AZD7254
Cat. No.:
HY-147744
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