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Cat. No.: HY-147744

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AZD7254

AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 1.0 nM against sonic Hh protein (shh).

For research use only. We do not sell to patients.

CAS No.: 1126366-28-6
Formula: C₂₄H₂₂N₄O₂
Molecular Weight:398.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

AZD7254 Chemical Structure

CAS No.: 1126366-28-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 1.0 nM against sonic Hh protein (shh)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
C3H 10T1/2	EC₅₀	1 nM Compound: 25	Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs	[PMID: 31862310]

In Vivo

AZD7254 (40 mg/kg; p.o.; twice daily for 10 days) exhibits 42% tumor growth inhibition in an HT29-MEF (murine embryonic fibroblast) co-implant xenograft model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1126366-28-6
Molecular Weight 398.46
Formula C₂₄H₂₂N₄O₂
SMILES

O=C(NC1=CC(C2=NC=CN2)=C(C)C=C1C)C3=CC=C(OCC4=NC=CC=C4)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang B, et al. Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254). Bioorg M [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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