Glasdegib hydrochloride
Based on 5 publication(s) in Google Scholar
Glasdegib hydrochloride is a potent and orally bioavailable smoothened inhibitor. Glasdegib hydrochloride (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM.
For research use only. We do not sell to patients.
- CAS No.: 1095173-64-0
- Formula: C21H23ClN6O
- Molecular Weight:410.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Glasdegib hydrochloride
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Biological Activity
Description
Chemical Information
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CAS No. 1095173-64-0
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Molecular Weight 410.90
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Formula C21H23ClN6O
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SMILES
CN1[C@H](C[C@@H](CC1)NC(NC2=CC=C(C=C2)C#N)=O)C3=NC4=CC=CC=C4N3.Cl
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Synonyms
PF-04449913 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Molecules
Development and Validation of a Rapid LC-MS/MS Method for Quantifying Alvocidib: In Silico and In Vitro Metabolic Stability Estimation in Human Liver Microsomes. [Abstract]2023 Mar 4;28(5):2368. PMID: 36903615 -
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Methods Mol Biol
2018:1711:351-398. PMID: 29344898
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glasdegib hydrochloride Related Classifications
HY-16391B Related Classifications
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