HTN3 - histatin 3 Gene

Also Known as PB; HIS2; HTN2; HTN5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3347

About HTN3

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,028,459-70,036,538 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 15 orthologues and 2 paralogues. Restricted expression toward salivary gland (RPKM 33773.0).

Summary

This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit Antibacterial, Antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]

HTN3 Products (1)

mRNA Protein Name
NM_000200.3 NP_000191.1 histatin-3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity IMP
IMP: Inferred from mutant phenotype
26775844 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23499434 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
32751915 GOA
Biological Process GO Annotation Evidence References Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
3286634 GOA
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
28261570 GOA
involved in defense response to fungus IDA
IDA: Inferred from direct assay
11083804 GOA
involved in defense response to fungus IMP
IMP: Inferred from mutant phenotype
28763199 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
3286634 GOA
involved in killing of cells of another organism IMP
IMP: Inferred from mutant phenotype
28763199 GOA
involved in positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
26775844 GOA
involved in positive regulation of wound healing IDA
IDA: Inferred from direct assay
18650243 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
3286634 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
32225006 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histatin-3

  • basic histidine-rich protein

HTN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HTN3 P15516 DNAJB11 Homo sapiens Q9UBS4
Validated Y2H
32296183
Cross
HTN3 P15516 rgpB Porphyromonas gingivalis P95493
Protease Assay
23499434
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HTN3 Proteins

Cat. No. Product Name Accession Purity
HY-P70298 Histatin-3/HTN3 Protein, Human P15516 (D20-N51) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Oral Candidiasis

  • Thrush

  • Candidiasis Of Mouth

  • Oral Moniliasis

  • Thrush, Oral

  • Candidiasis, Oral

  • Oral Thrush

  • Candidiasis

  • Equine Thrush
Candidiasis

  • Systemic Candidiasis

  • Invasive Candidiasis

  • Disseminated Candidiasis

  • Systemic Candida Infections

  • Candidiasis, Invasive
Candida Glabrata

  • Torulopsis Glabrata
Renal Artery Atheroma

  • Atherosclerosis Of Renal Artery

  • Renal Atherosclerosis

  • Atherosclerotic Renal Disease

  • Ras - [Renal Artery Stenosis]

  • Renal Arterial Arteriosclerosis

  • Renal Arterial Arteriosclerotic Disease

  • Renal Arterial Stricture

  • Renal Artery Stricture

  • Renal Artery Stenosis Of Unknown Cause

  • Renal Artery Stenosis Due To Atherosclerosis

  • Renal Artery Stenosis

  • Renal Artery Arteriosclerotic Disease

  • Renal Artery Arteriosclerosis
Dental Caries

  • Dental Caries Extending Into Pulp

  • Dental Caries Of Smooth Surface

  • Dental Caries Pit And Fissure

  • Smooth Surface Dental Caries

  • Dental Decay

  • Carious Teeth

  • Dental Cavity

  • Saprodontia

  • Teeth Decayed

  • Tooth Caries

  • Tooth Decay
Acute Apical Periodontitis

  • Acute Apical Periodontitis Of Pulpal Origin

  • Acute Apical Periodontitis Nos

  • Aap - [Acute Apical Periodontitis]
Renal Artery Disease

  • Renal Vascular Disease

  • Vascular Disorder Of Kidney

  • Renal Vascular Disorder
Human Immunodeficiency Virus Type 1

  • Aids

  • Hiv/Aids

  • Aids, Delayed/Rapid Progression To

  • Hiv-1, Susceptibility To

  • Hiv-1 Viremia, Susceptibility To

  • Human Immunodeficiency Virus Type 1, Susceptibility To

  • Hiv-1

  • Aids, Slow Progression To

  • Rapid Progression To Aids From Hiv1 Infection

  • Hiv1 Infection, Resistance To

  • Hiv1 Infection

  • Hiv-1 Viremia

  • Aids, Resistance To

  • Aids, Rapid Progression To

  • Hiv/Aids, Susceptibility To

  • Hiv-1, Resistance To

  • Hiv1, Resistance To

  • Hiv1

  • Hiv-1 Disease, Delayed Progression Of

  • Hiv-1 Disease, Rapid Progression Of

  • Hiv Infection, Resistance To

  • Hiv Type 1, Susceptibility To

  • Hiv Type 1

  • Hiv-1 Infection

  • Human Immunodeficiency Virus I Infection

  • Acquired Immunodeficiency Syndrome

  • Hiv-Infection/Aids
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06457 HTN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown