Histatin-3/HTN3 Protein, Human
Based on 1 Customer Validation
The Histatin-3/HTN3 protein is a key salivary component and a major precursor in the formation of the enamel film on the tooth surface. In addition to its structural role, histatin-3 also exhibits antibacterial and antifungal activity, particularly through its His3-(20-43)-peptide (histatin-5). Histatin-3/HTN3 Protein, Human is the recombinant human-derived Histatin-3/HTN3 protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The Histatin-3/HTN3 protein is a key salivary component and a major precursor in the formation of the enamel film on the tooth surface. In addition to its structural role, histatin-3 also exhibits antibacterial and antifungal activity, particularly through its His3-(20-43)-peptide (histatin-5). Histatin-3/HTN3 Protein, Human is the recombinant human-derived Histatin-3/HTN3 protein, expressed by E. coli , with tag free.
Background
Histatin-3/HTN3 Protein, a vital component of salivary proteins, plays a crucial role as a major precursor in the formation of the protective proteinaceous structure on tooth surfaces, known as the enamel pellicle. Beyond its structural function, histatin-3 exhibits notable antibacterial and antifungal activities, with its His3-(20-43)-peptide (histatin-5) demonstrating particular efficacy against C. albicans and C. neoformans, while also inhibiting Lys-gingipain and Arg-gingipain (rgpB) from P. gingivalis. This peptide additionally serves as a potent inhibitor of metalloproteinases MMP2 and MMP9. Intriguingly, the His3-(20-43)-peptide exists as a homodimer. Histatin-3, along with its His3-(20-43)-peptide counterpart, interacts with yeast SSA1 and SSA2 proteins, emphasizing its multifaceted roles in host defense and oral health.
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
P15516 (D20-N51)
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Molecular Construction
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N-term
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HTN3 (D20-N51)
Accession # P15516 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
HTN3; Histatin-5; Histatin 3; Histatin-6; HIS2; Histatin-7; Basic Histidine-Rich Protein; Histatin-8; Histidine-Rich Protein 3; Histatin-9; Histatin-3; HTN2; Hst 3; HTN5; PB; Hst; Histatin-4
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AA Sequence
DSHAKRHHGYKRKFHEKHHSHRGYRSNYLYDN
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Predicted Molecular Mass
4.4 kDa
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Molecular Weight
Approximately 9-12 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (232 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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