Idua - alpha-L-iduronidase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360904

Summary

Enables L-iduronidase activity and signaling receptor binding activity. Involved in glycosaminoglycan catabolic process. Located in coated vesicle and lysosome. Biomarker of gastric ulcer. Human ortholog(s) of this gene implicated in Scheie syndrome; mucopolysaccharidosis I; mucopolysaccharidosis Ih; and mucopolysaccharidosis Ih/s. Orthologous to human IDUA (alpha-L-iduronidase). [provided by Alliance of Genome Resources, Apr 2022]

Idua Products (1)

mRNA Protein Name
NM_001172084.1 NP_001165555.1 alpha-L-iduronidase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables L-iduronidase activity IDA
IDA: Inferred from direct assay
6138357 RGD
enables signaling receptor binding IMP
IMP: Inferred from mutant phenotype
6138357 RGD
Biological Process GO Annotation Evidence References Source
involved in glycosaminoglycan catabolic process IDA
IDA: Inferred from direct assay
6138357 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-L-iduronidase

  • Idual

  • iduronidase, alpha-L-

  • iduronidase, alpha-L-like

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99530 Valanafusp alfa 98.42% Phase 2
HY-P99694 Lepunafusp alfa Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W654272 4-Methylumbelliferyl-α-L-iduronide 2-sulfate sodium 98.77% Unkown
HY-RS06546 IDUA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17959 Idua Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24430 Idua Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Idua NCBI NCBI:3425