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IMPA1 - inositol monophosphatase 1 Gene

Also Known as IMP; IMPA; MRT59

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3612

About IMPA1

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:81,656,914-81,686,325 (from NCBI)

This gene has 13 transcripts (splice variants), 232 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 15.5), thyroid (RPKM 10.4) and 24 other tissues.

Summary

This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent Phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]

IMPA1 Products (3)

mRNA	Protein	Name
NM_001144878.2	NP_001138350.1	inositol monophosphatase 1 isoform 2
NM_001144879.2	NP_001138351.1	inositol monophosphatase 1 isoform 3
NM_005536.4	NP_005527.1	inositol monophosphatase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables inositol monophosphate 1-phosphatase activity	IDA IDA: Inferred from direct assay	17068342	GOA
enables inositol monophosphate 1-phosphatase activity	IMP IMP: Inferred from mutant phenotype	1377913	GOA
enables inositol monophosphate phosphatase activity	IDA IDA: Inferred from direct assay	9462881	GOA
enables lithium ion binding	IDA IDA: Inferred from direct assay	9462881	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	9462881	GOA
enables manganese ion binding	IDA IDA: Inferred from direct assay	9462881	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17068342	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in phosphate-containing compound metabolic process	IMP IMP: Inferred from mutant phenotype	1377913	GOA
involved in phosphatidylinositol biosynthetic process	IMP IMP: Inferred from mutant phenotype	1377913	GOA
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	1377913	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	1377913	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IMPA1 Protein Structure

Inositol_P

0
100
200
277 a.a.

Protein Preferred Names	Protein Names
inositol monophosphatase 1	D-galactose 1-phosphate phosphatase

IMPA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IMPA1	P29218	IMPA2	Homo sapiens	O14732	Anti Tag CoIP	35271311
Intra	IMPA1	P29218	IMPA2	Homo sapiens	O14732	Validated Y2H	25416956
Intra	IMPA1	P29218	IMPA1	Homo sapiens	P29218-1	Y2H Array	31515488
Intra	IMPA1	P29218	IMPA1	Homo sapiens	P29218	Y2H Pooling	16189514
Intra	IMPA1	P29218	IMPA1	Homo sapiens	P29218	Y2H Pooling	19447967
Intra	IMPA1	P29218	SIRT1	Homo sapiens	Q96EB6	Anti Tag CoIP	33961781
Intra	IMPA1	P29218	IMPA1	Homo sapiens	P29218	Y2H Array	25416956
Intra	IMPA1	P29218	METTL18	Homo sapiens	O95568	Anti Tag CoIP	33961781
Intra	IMPA1	P29218	E6	Human papillomavirus 5	P06930	Y2H Array	22810586
Intra	IMPA1	P29218	IMPA1	Homo sapiens	P29218	Y2H	21516116
Intra	IMPA1	P29218	Impa1	Rattus norvegicus	P97697	X-Ray Diffraction	8068621

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IMPA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70335	IMPA1 Protein, Human (His)	P29218-1 (M1-D277)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Recessive 59	MRT59 Mental Retardation, Autosomal Recessive 59 Autosomal Recessive Intellectual Developmental Disorder 59
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Mood Disorder	Mood Disorders Episodic Mood Disorder
Spastic Paraplegia, Optic Atrophy, And Neuropathy	Spoan Syndrome SPOAN Spastic Paraplegia, Optic Atropy, And Neuropathy Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Developmental And Epileptic Encephalopathy 11	Epileptic Encephalopathy, Early Infantile, 11 DEE11 Eiee11 Developmental And Epileptic Encephalopathy, 11 Early Infantile Epileptic Encephalopathy 11 Encephalopathy, Developmental And Epileptic, Type 11
Cardiomyopathy, Familial Hypertrophic, 1	Asymmetric Septal Hypertrophy Familial Hypertrophic Cardiomyopathy Hypertrophic Cardiomyopathy 1 CMH1 Hypertrophic Cardiomyopathy 19 CMH Ventricular Hypertrophy, Hereditary Ash Hypertrophic Subaortic Stenosis, Idiopathic Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Hypertrophic, 1, Digenic Cardiomyopathy, Familial Hypertrophic 1 Hcm Hereditary Ventricular Hypertrophy Idiopathic Hypertrophic Subaortic Stenosis Hypertrophic Cardiomyopathy Cardiomyopathy, Hypertrophic, Familial Cardiomyopathy, Hypertrophic, 1 Familial Asymmetric Septal Hypertrophy Heritable Hypertrophic Cardiomyopathy Fhc Cardiomyopathy, Hypertrophic, Familial, Type 1
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17572A	Atosiban acetate	Antagonist	98.87%	Unkown

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1390	d[Cha4]-AVP	Agonist	98.81%	Unkown
HY-125053A	Batifiban TFA	Antagonist	99.70%	Unkown
HY-125053	Batifiban		/	Unkown
HY-P10046	[Deamino-Pen1,Val4,D-Arg8]-vasopressin	Inhibitor	/	Unkown
HY-P4397	(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin		/	Unkown
HY-P4897	[Gly9-OH]-Atosiban		/	Unkown
HY-RS06795	IMPA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P5006	(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin	Antagonist	/	Unkown
HY-RS19447	Impa1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25939	Impa1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IMPA1	VGNC	VGNC:42007
Bos taurus	IMPA1	VGNC	VGNC:30184
Mus musculus	IMPA1	MGD	MGI:1933158
Macaca mulatta	IMPA1	VGNC	VGNC:84008
Rattus norvegicus	IMPA1	RGD	RGD:69254
Felis catus	IMPA1	VGNC	VGNC:67796
Others	IMPA1	NCBI