Xrn2 - 5'-3' exoribonuclease 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362229

Summary

Predicted to enable exoribonuclease activity, producing 5'-phosphomonoesters; identical protein binding activity; and nucleic acid binding activity. Involved in hippocampus development; neuron differentiation; and retina development in camera-type eye. Located in nucleus. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma and lung Cancer. Orthologous to human XRN2 (5'-3' exoribonuclease 2). [provided by Alliance of Genome Resources, Apr 2022]

Xrn2 Products (1)

mRNA Protein Name
NM_001108596.2 NP_001102066.2 5'-3' exoribonuclease 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in hippocampus development IEP
IEP: Inferred from expression pattern
23933240 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
23933240 RGD
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
23700402 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

5'-3' exoribonuclease 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173593 Adenosine-3',5'-bisphosphate Inhibitor / Unkown
HY-RS15903 XRN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20840 Xrn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27354 Xrn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xrn2 NCBI NCBI:22803