Melk - maternal embryonic leucine zipper kinase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362510

About Melk

Primary_assembly 5: 58,540,449-58,600,937 forward strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 217 orthologues, 26 paralogues and is associated with 2 phenotypes. Biased expression in Thymus (RPKM 71.4), Testes (RPKM 24.5) and 8 other tissues.

Summary

Predicted to enable calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of apoptotic process; and protein autophosphorylation. Predicted to act upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress. Predicted to be located in cell cortex and plasma membrane. Orthologous to human MELK (maternal embryonic leucine zipper kinase). [provided by Alliance of Genome Resources, Apr 2022]

Melk Products (1)

mRNA Protein Name
NM_001395606.1 NP_001382535.1 maternal embryonic leucine zipper kinase

Melk Protein Structure

STKc_MELK

STKc_MELK: cd14078 (6 - 262)

UBA_MELK

UBA_MELK: cd14341 (280 - 331)

MELK_C

MELK_C: cd12198 (546 - 640)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 643 a.a.
Protein Preferred Names Protein Names

maternal embryonic leucine zipper kinase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15512 OTSSP167 Inhibitor 99.27% Phase 2
HY-15512A OTSSP167 hydrochloride Inhibitor 99.78% Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100368A MELK-8a hydrochloride Inhibitor 99.31% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-101515 MELK-IN-1 Inhibitor 98.03% Unkown
HY-12420 JNJ-47117096 hydrochloride Inhibitor 99.67% Unkown
HY-122665 HTH-01-091 Inhibitor 99.81% Unkown
HY-100368 MELK-8a Inhibitor 98.32% Unkown
HY-122665A HTH-01-091 TFA Inhibitor 99.48% Unkown
HY-155748 Antitumor agent-116 Inhibitor / Unkown
HY-N17632 Moracin G Inhibitor / Unkown
HY-12420A JNJ-47117096 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Melk NCBI NCBI:9833