Rrm2 - ribonucleotide reductase regulatory subunit M2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362720

Summary

Predicted to enable ferric iron binding activity; protein homodimerization activity; and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in mitotic cell cycle; positive regulation of cell population proliferation; and pyrimidine nucleobase metabolic process. Located in nuclear envelope. Used to study endometrial adenocarcinoma. Biomarker of urinary bladder Cancer. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human RRM2 (ribonucleotide reductase regulatory subunit M2). [provided by Alliance of Genome Resources, Apr 2022]

Rrm2 Products (1)

mRNA Protein Name
NM_001025740.2 NP_001020911.1 ribonucleoside-diphosphate reductase subunit M2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17404105 RGD
involved in pyrimidine nucleobase metabolic process IEP
IEP: Inferred from expression pattern
10204803 RGD
Cellular Component GO Annotation Evidence References Source
located in nuclear envelope IDA
IDA: Inferred from direct assay
2205248 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ribonucleoside-diphosphate reductase subunit M2

  • Ribonucleotide reductase 2

  • ribonucleotide reductase M2 polypeptide

  • ribonucleotide reductase small chain

  • ribonucleotide reductase small subunit

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-30272 Monobenzone 99.93% Unkown
HY-B2116 Osalmid Inhibitor 99.91% Unkown

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0527 Pentagalloylglucose 99.57% Unkown
HY-P5960 PTBP1-RNA-binding inhibitor P6 TFA 98.59% Unkown
HY-153898 rTRD01 Ligand 99.10% Unkown
HY-153736 NSC 194308 99.86% Unkown
HY-112358 GW8510 Inhibitor 99.04% Unkown
HY-RS12286 RRM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12287 RRM2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16616 Rrm2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21746 Rrm2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23051 Rrm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28263 Rrm2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rrm2 NCBI NCBI:6241