MAP2K7 - Map2k7 mitogen activated protein kinase kinase 7 Gene

Also Known as JNKK; Mek7; Mkk7; Jnkk2; Mapkk7

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 363855

Summary

Enables several functions, including ATP binding activity; JUN kinase kinase activity; and magnesium ion binding activity. Involved in several processes, including JNK cascade; cellular response to sorbitol; and positive regulation of JNK cascade. Located in cytosol and nucleus. Orthologous to human MAP2K7 (mitogen-activated protein kinase kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

MAP2K7 Products (2)

mRNA Protein Name
NM_001025425.2 NP_001020596.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 1
NM_001401207.1 NP_001388136.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
10051439 RGD
enables JUN kinase kinase activity IDA
IDA: Inferred from direct assay
10051439 RGD
enables MAP kinase kinase activity IDA
IDA: Inferred from direct assay
10051439 RGD
enables magnesium ion binding IDA
IDA: Inferred from direct assay
10051439 RGD
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: Inferred from physical interaction
14575811 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15816852 RGD
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IDA
IDA: Inferred from direct assay
10051439 RGD
involved in cellular response to osmotic stress IDA
IDA: Inferred from direct assay
10051439 RGD
involved in cellular response to sorbitol IEP
IEP: Inferred from expression pattern
20550965 RGD
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
10051439 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
12514131 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
20550965 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
10051439 RGD
involved in response to osmotic stress IDA
IDA: Inferred from direct assay
10051439 RGD
involved in stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
10051439 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 7

  • JNK kinase 2

  • JNK-activating kinase 2

  • JNKK 2

  • MAP kinase kinase 7

  • MAPK/ERK kinase 7

  • MAPKK 7

  • MEK 7

  • c-Jun N-terminal kinase kinase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-171178 DK2403 98.24% Unkown
HY-D2415 BODIPY-FL staurosporine 95.4% Unkown
HY-RS08045 MAP2K7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19790 Map2k7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26286 Map2k7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens MAP2K7 NCBI NCBI:5609