KRT9 - keratin 9 Gene

Also Known as K9; CK-9; EPPK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3857

About KRT9

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,565,836-41,572,059 (from NCBI)

This gene has 2 transcripts (splice variants), 72 orthologues, 68 paralogues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes the type I keratin 9, an intermediate filament chain expressed only in the terminally differentiated epidermis of palms and soles. Mutations in this gene cause epidermolytic palmoplantar keratoderma. [provided by RefSeq, Jul 2008]

KRT9 Products (1)

mRNA	Protein	Name
NM_000226.4	NP_000217.2	keratin, type I cytoskeletal 9

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in intermediate filament organization	IMP IMP: Inferred from mutant phenotype	10218578	GOA
involved in skin development	IDA IDA: Inferred from direct assay	7507869	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT9 Protein Structure

Filament

0
100
200
300
400
500
623 a.a.

Protein Preferred Names	Protein Names
keratin, type I cytoskeletal 9	cytokeratin 9

KRT9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83106	Cytokeratin 9 Antibody (YA2851)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P83106A	Cytokeratin 9 Antibody (YA2851)(PBS only)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P84275	Cytokeratin 9 Antibody (YA3972)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat
HY-P84275A	Cytokeratin 9 Antibody (YA3972)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Palmoplantar Keratoderma, Epidermolytic	Epidermolytic Palmoplantar Keratoderma EPPK Keratosis Palmaris Et Plantaris Familiaris Tylosis Keratosis Of Greither Diffuse Nonepidermolytic Palmoplantar Keratoderma Keratoderma, Palmoplantar, Epidermolytic Unna-Thost Palmoplantar Keratoderma Epidermolytic Palmoplantar Keratoderma Of Voerner Ppke Keratoderma, Epidermolytic Palmoplantar Palmoplantar Keratoderma, Vorner Type Hyperkeratosis, Localized Epidermolytic Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type Epidermolytic Palmoplantar Keratoderma Of Vörner Hyperkeratosis Palmoplantar Localized Epidermolytic Diffuse Neppk Ppk Diffusa Circumscripta Thost-Unna Disease Thost-Unna Palmoplantar Keratoderma Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type Epidermolytic Palmoplantar Keratoderma Of Vorner Ehppk Epidermolytic Unna-Thost Disease Localized Epidermolytic Hyperkeratosis Palmoplantar Keratoderma Vorner Type Unilateral Palmoplantar Verrucous Nevus UPVN Keratoderma, Palmoplantar, Diffuse Hyperkeratosis Palmoplantar Keratoderma, Nonepidermolytic Epidermolytic Palmoplantar Keratoderma Vorner Type Type B Tylosis Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas Type A Tylosis
Palmoplantar Keratosis	Palmoplantar Keratoderma Keratosis Palmaris Et Plantaris Palmo-Plantar Keratodermas Keratoderma, Palmoplantar Keratoderma Palmoplantar Keratoderma, Palmoplantar, Diffuse Hyperkeratosis Of Palms And Soles Palmoplantar Hyperkeratosis
Knuckle Pads	Garrod Pads
Keratosis	Actinic Keratosis Hyperkeratosis
Palmoplantar Keratoderma, Nonepidermolytic	Nonepidermolytic Palmoplantar Keratoderma NEPPK Tylosis Unna-Thost Syndrome Keratoderma, Palmoplantar, Diffuse Ppkne Keratoderma, Nonepidermolytic Palmoplantar Diffuse Nonepidermolytic Palmomplantar Keratoderma Thost-Unna Syndrome Non-Epidermolytic Palmoplantar Keratoderma Autosomal Dominant Diffuse Palmoplantar Keratoderma, Norrbotten Type Diffuse Palmoplantar Keratoderma, Bothnian Type Krt1-Related Diffuse Nonepidermolytic Keratoderma Krt1-Related Diffuse Neppk Keratoderma, Palmoplantar, Non-Epidermolytic Nonepidermolytic Unna-Thost Disease Non-Epidermolytic Unna-Thost Disease Keratoderma, Palmoplantar, Nonepidermolytic Hyperkeratosis
Epidermolytic Hyperkeratosis	Bullous Congenital Ichthyosiform Erythroderma Bullous Ichthyosiform Erythroderma EHK Bullous Erythroderma Ichthyosiformis Congenita Of Brocq Bcie Bie Epidermolytic Ichthyosis Ichthyosis Bullosa Of Siemens Superficial Epidermolytic Ichthyosis Hyperkeratosis, Epidermolytic Congenital Bullous Ichthyosiform Erythroderma Bullous Type Ichthyosis Epidermolytic Palmoplantar Hyperkeratosis Bullous Ichthyosiform Erythroderma Congenita Bullous Erythroderma Ichthyosiforme Sei Epidermolytic Hyperkeratosis Late-Onset Epidermolytic Hyperkeratosis, Late-Onset
Acrokeratoderma, Hereditary Papulotranslucent	Hereditary Papulotranslucent Acrokeratoderma
Pachyonychia Congenita 1	Pachyonychia Congenita Jadassohn-Lewandowsky Syndrome Pachyonychia Congenita Syndrome PC1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type Congenital Pachyonychia Pachyonychia Congenita, Type 1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly Jadassohn-Lewandowsky Syndrome, Formerly Jackson-Lawler Type Pachyonychia Congenita Pachyonychia Congenita Type 1 Jackson-Lawler Syndrome Jadassohn-Lewandowski Syndrome Pc Pachyonychia Congenita Jackson-Lawler Type Pachyonychia Congenita Jadassohn-Lewandowsky Type Pachyonychia Congenita Jackson Lawler Type Pc-1 Pachyonychia Congenita, Jadassohn Lewandowsky Type Pachyonychia Congenita, Type 2
Epidermolytic Acanthoma
Palmoplantar Keratoderma, Nonepidermolytic, Focal 1	Focal Nonepidermolytic Palmoplantar Keratoderma Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma FNEPPK1 Ppkfne Keratoderma, Focal Nonepidermolytic Palmoplantar Palmoplantar Keratoderma, Nonepidermolytic, Focal Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas Fneppk Focal Nonepidermolytic Palmoplantar Keratoderma 1 Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1 Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Opisthorchiasis	Infection By Opisthorchis Infection Due To Opisthorchis Infection Due To Cat Liver Fluke Infection By Cat Liver Fluke Opisthorchiosis Cat Liver Fluke Fever Cat Liver Fluke Disease Opisthorchis Infestation Cat Liver Fluke Infestation
Pinguecula
Conjunctival Degeneration
Epidermolysis Bullosa Simplex Localized Type	Epidermolysis Bullosa Simplex, Weber-Cockayne Type Weber-Cockayne Syndrome Ebs-Loc Epidermolysis Bullosa Simplex Of Palms And Soles Epidermolysis Bullosa Simplex Weber-Cockayne Type Epidermolysis Bullosa Simplex, Localized Epidermolysis Bullosa Of Hands And Feet Weber-Cockayne Type Epidermolysis Bullosa Simplex Localized Epidermolysis Bullosa Simplex Localized Ebs
Glomangioma
Benign Perivascular Tumor	Benign Pericytic Neoplasm
Epidermolysis Bullosa Simplex	Ebs Epidermolysis Bullosa Intraepidermic Epidermolytic Epidermolysis Bullosa
Epidermolysis Bullosa Dystrophica	Dystrophic Epidermolysis Bullosa Deb Dermolytic Epidermolysis Bullosa Epidermolysis Bullosa, Dermolytic Epidermolysis Bullosa, Dystrophic Epidermolysis Bullosa Dystrophic Dystrophic Eb - [Epidermolysis Bullosa]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07472	KRT9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KRT9	MGD	MGI:96696
Bos taurus	KRT9	VGNC	VGNC:30745
Macaca mulatta	KRT9	VGNC	VGNC:74215
Canis familiaris	KRT9	VGNC	VGNC:42537
Felis catus	KRT9	VGNC	VGNC:67992
Rattus norvegicus	KRT9	RGD	RGD:628785
Others	KRT9	NCBI