CENPW - centromere protein W Gene

Also Known as CUG2; CENP-W; C6orf173

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 387103

About CENPW

Cytogenetic location: 6q22.32 Genomic coordinates (GRCh38): 6:126,340,115-126,483,320 (from NCBI)

This gene has 3 transcripts (splice variants) and 124 orthologues. Broad expression in bone marrow (RPKM 2.8), testis (RPKM 2.0) and 20 other tissues.

Summary

Predicted to enable DNA binding activity and protein heterodimerization activity. Involved in chromosome segregation; kinetochore assembly; and mitotic cell cycle. Located in kinetochore and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CENPW Products (3)

mRNA Protein Name
NM_001012507.4 NP_001012525.1 centromere protein W isoform b
NM_001286524.2 NP_001273453.1 centromere protein W isoform a
NM_001286525.2 NP_001273454.1 centromere protein W isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19070575 GOA
Biological Process GO Annotation Evidence References Source
involved in chromosome organization IMP
IMP: Inferred from mutant phenotype
21695110 GOA
involved in chromosome segregation IMP
IMP: Inferred from mutant phenotype
21695110 GOA
involved in kinetochore assembly IMP
IMP: Inferred from mutant phenotype
21695110 GOA
involved in mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
21695110 GOA
Cellular Component GO Annotation Evidence References Source
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
19533040 GOA
part of inner kinetochore IPI
IPI: Inferred from physical interaction
36085283 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
21695110 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPW Protein Structure

CENP-W

CENP-W: CENP-W protein (1 - 88)

  • 0
  • 88 a.a.
Protein Preferred Names Protein Names

centromere protein W

  • cancer-up-regulated gene 2 protein

CENPW Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CENPW Q5EE01 CENPT Homo sapiens Q96BT3
Anti Tag CoIP
19533040
Intra
CENPW Q5EE01 CENPT Homo sapiens Q96BT3
Anti Tag CoIP
33961781
Intra
CENPW Q5EE01 CENPT Homo sapiens Q96BT3
Y2H
19533040
Intra
CENPW Q5EE01 CENPT Homo sapiens Q96BT3
GMS
22304917
Intra
CENPW Q5EE01 CENPT Homo sapiens Q96BT3
Pull Down
19533040
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Acromesomelic Dysplasia 2b

  • Fibular Hypoplasia And Complex Brachydactyly

  • Du Pan Syndrome

  • AMD2B

  • Dupans

  • Acromesomelic Dysplasia-2b

  • Fibular Aplasia-Complex Brachydactyly Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02494 CENPW Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20880 Cenpw Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27397 Cenpw Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CENPW VGNC VGNC:60763
Mus musculus CENPW MGD MGI:1913561
Rattus norvegicus CENPW RGD RGD:1593465
Canis familiaris CENPW VGNC VGNC:39114
Bos taurus CENPW VGNC VGNC:27187
Macaca mulatta CENPW VGNC VGNC:71071
Others CENPW NCBI