CENPT - centromere protein T Gene

Homo sapiens

Also known as SSMGA; CENP-T; C16orf56

Gene ID: 80152 | Gene type: protein coding

About CENPT

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,828,157-67,847,693 (from NCBI)

This gene has 35 transcripts (splice variants), 176 orthologues and is associated with 1 phenotype. Ubiquitous expression in skin (RPKM 26.3), testis (RPKM 20.1) and 25 other tissues.

Summary

The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]

CENPT Products(1)

mRNA	Protein	Name
NM_025082.4	NP_079358.3	centromere protein T

CENPT Protein Structure

CENP-T_C

0
100
200
300
400
500
561 a.a.

Protein Preferred Names

Protein Names

centromere protein T

interphase centromere complex protein 22

Related Diseases

Diseases

Alias

Short Stature And Microcephaly With Genital Anomalies

SSMGA

Methylmalonic Aciduria And Homocystinuria, Cblx Type

Mental Retardation, X-Linked 3	Methylmalonic Acidemia With Homocystinuria, Type Cblx
MAHCX	Intellectual Developmental Disorder, X-Linked 3
Xlid3	Mrx3
Methylmalonic Acidemia And Homocysteinemia Cblx Type	Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblx
Methylmalonic Aciduria With Homocystinuria, Type Cblx	Methylmalonic Acidemia And Homocysteinemia, Cblx Type
Methylmalonic Aciduria And Homocysteinemia, Cblx Type	Methylmalonic Aciduria And Homocysteinemia , Cblx Type
Mental Retardation, X-Linked, Type 3

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02491	CENPT Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CENPT	MGD	MGI:2443939
Rattus norvegicus	CENPT	RGD	RGD:1309383
Macaca mulatta	CENPT	VGNC	VGNC:71103
Felis catus	CENPT	VGNC	VGNC:60761
Bos taurus	CENPT	VGNC	VGNC:27185

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