CENPT - centromere protein T Gene

Also Known as SSMGA; CENP-T; C16orf56

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80152

About CENPT

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,828,157-67,847,693 (from NCBI)

This gene has 35 transcripts (splice variants), 176 orthologues and is associated with 1 phenotype. Ubiquitous expression in skin (RPKM 26.3), testis (RPKM 20.1) and 25 other tissues.

Summary

The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during Mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]

CENPT Products (1)

mRNA	Protein	Name
NM_025082.4	NP_079358.3	centromere protein T

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19070575	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chromosome organization	IMP IMP: Inferred from mutant phenotype	21695110	GOA
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	21529714	GOA
involved in kinetochore assembly	IMP IMP: Inferred from mutant phenotype	21529714	GOA
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	21695110	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	21695110	GOA
part of inner kinetochore	IPI IPI: Inferred from physical interaction	36085283	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	21529714	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPT Protein Structure

CENP-T_C

0
100
200
300
400
500
561 a.a.

Protein Preferred Names	Protein Names
centromere protein T	interphase centromere complex protein 22

CENPT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CENPT	Q96BT3	CENPW	Homo sapiens	Q5EE01	Pull Down	19533040

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Short Stature And Microcephaly With Genital Anomalies	SSMGA
Methylmalonic Aciduria And Homocystinuria, Cblx Type	Mental Retardation, X-Linked 3 Methylmalonic Acidemia With Homocystinuria, Type Cblx MAHCX Intellectual Developmental Disorder, X-Linked 3 Xlid3 Mrx3 Methylmalonic Acidemia And Homocysteinemia Cblx Type Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblx Methylmalonic Aciduria With Homocystinuria, Type Cblx Methylmalonic Acidemia And Homocysteinemia, Cblx Type Methylmalonic Aciduria And Homocysteinemia, Cblx Type Methylmalonic Aciduria And Homocysteinemia , Cblx Type Mental Retardation, X-Linked, Type 3
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02491	CENPT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CENPT	MGD	MGI:2443939
Rattus norvegicus	CENPT	RGD	RGD:1309383
Macaca mulatta	CENPT	VGNC	VGNC:71103
Felis catus	CENPT	VGNC	VGNC:60761
Bos taurus	CENPT	VGNC	VGNC:27185
Others	CENPT	NCBI