NPSR1 - neuropeptide S receptor 1 Gene

Also Known as GPRA; NPSR; VRR1; ASRT2; PGR14; GPR154

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 387129

About NPSR1

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:34,658,218-34,878,332 (from NCBI)

This gene has 9 transcripts (splice variants), 382 orthologues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

NPSR1 Products (5)

mRNA Protein Name
NM_001300933.2 NP_001287862.1 neuropeptide S receptor isoform B short
NM_001300934.2 NP_001287863.1 neuropeptide S receptor isoform F
NM_001300935.2 NP_001287864.1 neuropeptide S receptor isoform G
NM_207172.2 NP_997055.1 neuropeptide S receptor isoform A
NM_207173.2 NP_997056.1 neuropeptide S receptor isoform B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables neuropeptide receptor activity IDA
IDA: Inferred from direct assay
16790440 GOA
Biological Process GO Annotation Evidence References Source
involved in neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
15947423 GOA
involved in positive regulation of release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
16790440 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15947423 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
15947423 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPSR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (66 - 330)

  • 0
  • 100
  • 200
  • 300
  • 371 a.a.
Protein Preferred Names Protein Names

neuropeptide S receptor

  • G-protein coupled receptor 154

Related Diseases

Diseases Alias
Asthma-Related Traits 2

  • Asthma-Related Traits, Susceptibility To, 2

  • ASRT2

  • Asthma, Susceptibility To, 2

  • Asthma 2

  • Asthma-Related Traits, Susceptibility To, Type 2
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Agoraphobia

  • Fear Of Open Spaces

  • Phobia Of Going Out
Allergic Asthma

  • Atopic Asthma

  • Extrinsic Asthma

  • Extrinsic Asthma With Acute Exacerbation

  • Extrinsic Asthma With Status Asthmaticus

  • Asthma Allergic

  • Atopic Asthma, Susceptibility To

  • Ige-Mediated Allergic Asthma

  • Allergen-Induced Asthma

  • Allergic Asthma Without Stated Status Asthmaticus

  • Predominantly Allergic Asthma Without Stated Status Asthmaticus

  • Predominantly Allergic Asthma

  • Allergic Asthma Nos

  • Catarrh With Asthma

  • Allergic Bronchitis Nos

  • Extrinsic Allergic Asthma

  • Predominantly Allergic Asthma With Stated Status Asthmaticus
Dermatitis

  • Eczema

  • Skin Inflammation

  • Inflammatory Dermatosis
Panic Disorder

  • Panic Anxiety Syndrome

  • Panic

  • Panic Disorder 1

  • Episodic Paroxysmal Anxiety Disorder
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Anxiety

  • Anxiety Disorder

  • Anxiety Disorders

  • Anxiety State

  • Anxieties

  • Anxiety Neurosis
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Childhood-Onset Asthma

  • Childhood Asthma

  • Asthma Childhood
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-186034 R06039-691 Agonist 99.67% Unkown
HY-186036 R06039-641 Agonist 98.76% Unkown
HY-175813 NPSR1 antagonist-1 / Unkown
HY-186032 R06039-693 Agonist / Unkown
HY-186033 R06039-696 Agonist / Unkown
HY-P12119 RTI-263 Agonist / Unkown
HY-RS09503 NPSR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180875 NPSR1 modulator-1 / Unkown
HY-RS21667 Npsr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28185 Npsr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NPSR1 VGNC VGNC:32216
Macaca mulatta NPSR1 VGNC VGNC:81730
Rattus norvegicus NPSR1 RGD RGD:1564154
Felis catus NPSR1 VGNC VGNC:63875
Mus musculus NPSR1 MGD MGI:2441738
Canis familiaris NPSR1 VGNC VGNC:54789
Others NPSR1 NCBI