LIN28B - lin-28 homolog B Gene

Also Known as CSDD2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 389421

About LIN28B

Cytogenetic location: 6q16.3-q21 Genomic coordinates (GRCh38): 6:104,937,026-105,083,332 (from NCBI)

This gene has 3 transcripts (splice variants), 231 orthologues, 4 paralogues and is associated with 1 phenotype. Restricted expression toward placenta (RPKM 24.7).

Summary

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and Cancer cell lines. It is negatively regulated by MicroRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of MicroRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]

LIN28B Products (2)

mRNA Protein Name
NM_001004317.4 NP_001004317.1 protein lin-28 homolog B isoform 1
NM_001410939.1 NP_001397868.1 protein lin-28 homolog B isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
19703396 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19703396 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in RNA 3'-end processing IMP
IMP: Inferred from mutant phenotype
19703396 GOA
involved in RNA destabilization IDA
IDA: Inferred from direct assay
18951094 GOA
involved in miRNA catabolic process IMP
IMP: Inferred from mutant phenotype
19703396 GOA
involved in negative regulation of pre-miRNA processing IDA
IDA: Inferred from direct assay
18951094 GOA
involved in negative regulation of primary miRNA processing IDA
IDA: Inferred from direct assay
18951094 GOA
involved in positive regulation of miRNA catabolic process IMP
IMP: Inferred from mutant phenotype
18951094 GOA
involved in pre-miRNA processing IMP
IMP: Inferred from mutant phenotype
19703396 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIN28B Protein Structure

CSD

CSD: 'Cold-shock' DNA-binding domain (31 - 101)

zf-CCHC

zf-CCHC: Zinc knuckle (128 - 142)

  • 0
  • 100
  • 200
  • 250 a.a.
Protein Preferred Names Protein Names

protein lin-28 homolog B

  • Lin-28.2

LIN28B Antibodies

Cat. No. Product Name Application Reactivity
HY-P80211 Lin28B Antibody (YA709) WB, ICC/IF, IHC-P Human

Related Diseases

Diseases Alias
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Acrocephalopolysyndactyly Type Iii

  • Sakati Syndrome

  • Sakati-Nyhan Syndrome

  • Acps With Leg Hypoplasia

  • Acps Iii

  • Acrocephalopolysyndactyly Type 3

  • Sakati-Nyhan-Tisdale Syndrome
Perlman Syndrome

  • Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor

  • PRLMNS

  • Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism

  • Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor

  • Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor

  • Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor

  • Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism

  • Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome

  • Renal Hamartomas Nephroblastomatosis And Fetal Gigantism

  • Nephroblastoma

  • Fetal Macrosomia
Central Precocious Puberty

  • Cpp

  • Gonadotropin-Dependant Precocious Puberty

  • Gonadotropin-Dependent Precocious Puberty

  • Precocious Puberty, Central
Breast Adenocarcinoma

  • Mammary Adenocarcinoma

  • Adenocarcinoma Of Breast
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Atypical Teratoid Rhabdoid Tumor

  • Rhabdoid Tumor Predisposition Syndrome

  • Rtps

  • Atypical Teratoid/Rhabdoid Tumor

  • Rhabdoid Predisposition Syndrome

  • Familial Posterior Fossa Brain Tumor Of Infancy

  • Familial Rhabdoid Tumor

  • At/Rt

  • Atypical Teratoid Rhabdoid Tumour

  • Atypical Teratoid/Rhabdoid Tumour

  • Rhabdoid Tumor Of The Cns

  • Rhabdoid Tumour Of The Cns

  • Familial Posterior Fossa Brain Tumor Syndrome

  • Hereditary Swi/Snf Deficiency Syndrome

  • Atrt
Adult Hepatocellular Carcinoma

  • Adult Primary Hepatocellular Carcinoma

  • Adult Hepatoma

  • Adult Hcc
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115686 8-Azaadenosine Inhibitor 99.94% Unkown
HY-168437 LIN28-IN-2 99.51% Unkown
HY-177782 SB1349 Degrader / Unkown
HY-RS07672 LIN28B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19515 Lin28b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26010 Lin28b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus LIN28B VGNC VGNC:108131
Canis familiaris LIN28B VGNC VGNC:42684
Felis catus LIN28B VGNC VGNC:102449
Rattus norvegicus LIN28B RGD RGD:1597432
Macaca mulatta LIN28B VGNC VGNC:74175
Mus musculus LIN28B MGD MGI:3584032
Others LIN28B NCBI