NUGGC - nuclear GTPase, germinal center associated Gene

Also Known as SLIPGC; C8orf80; SLIP-GC; HMFN0672

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 389643

About NUGGC

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:28,021,964-28,083,936 (from NCBI)

This gene has 2 transcripts (splice variants) and 216 orthologues. Biased expression in lymph node (RPKM 5.9), liver (RPKM 3.6) and 9 other tissues.

Summary

Enables GTPase activity. Involved in cellular response to lipopolysaccharide; negative regulation of apoptotic process; and regulation of nuclear cell cycle DNA replication. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NUGGC Products (1)

mRNA Protein Name
NM_001010906.2 NP_001010906.1 nuclear GTPase SLIP-GC

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables GTPase activity IDA
IDA: Inferred from direct assay
19734146 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
19734146 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19734146 GOA
involved in regulation of nuclear cell cycle DNA replication IMP
IMP: Inferred from mutant phenotype
19734146 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUGGC Protein Structure

Dynamin_N

Dynamin_N: Dynamin family (103 - 323)

  • 0
  • 200
  • 400
  • 600
  • 796 a.a.
Protein Preferred Names Protein Names

nuclear GTPase SLIP-GC

  • GTPase SLIP-GC

Related Diseases

Diseases Alias
Endometrial Stromal Sarcoma

  • Ess

  • Endometrial Stromal Sarcoma, High Grade

  • Undifferentiated Endometrial Sarcoma

  • Stromal Sarcoma Of The Corpus Uteri

  • Sarcoma Endometrial Stromal

  • Sarcoma, Endometrial Stromal

  • Undifferentiated Stromal Sarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09679 NUGGC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NUGGC VGNC VGNC:32347
Rattus norvegicus NUGGC RGD RGD:1562099
Felis catus NUGGC VGNC VGNC:63917
Canis familiaris NUGGC VGNC VGNC:44041
Mus musculus NUGGC MGD MGI:2685446
Macaca mulatta NUGGC VGNC VGNC:75497