E2f1 - E2F transcription factor 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 399489

Summary

Enables protein kinase binding activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to hypoxia; cellular response to nerve growth factor stimulus; and positive regulation of glial cell proliferation. Located in cytoplasm and nucleus. Biomarker of Huntington's disease and pancreatic Cancer. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Orthologous to human E2F1 (E2F transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

E2f1 Products (1)

mRNA Protein Name
NM_001100778.1 NP_001094248.1 transcription factor E2F1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9697699 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
18367454 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18096822 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to fatty acid IEP
IEP: Inferred from expression pattern
19180667 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
19088195 RGD
involved in cellular response to nerve growth factor stimulus IDA
IDA: Inferred from direct assay
18367454 RGD
involved in positive regulation of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
21637599 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
17147820 RGD
Cellular Component GO Annotation Evidence References Source
located in nuclear chromosome IDA
IDA: Inferred from direct assay
24250814 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor E2F1

  • E2F-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-16270 Kevetrin / Phase 2
HY-183118 CID-078 / Phase 1

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156135 NSC194598 98.90% Unkown
HY-162384 EPIC-0628 Inhibitor 98.66% Unkown
HY-148880 VHLL-BCN 96.30% Unkown
HY-117857 MRT00033659 99.77% Unkown
HY-RS04110 E2F1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123612 JAS239 Inhibitor / Unkown
HY-175397 Dth / Unkown
HY-182902 IHMT-15137 / Unkown
HY-RS15353 UBE2L3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17052 E2f1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23496 E2f1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens E2f1 NCBI NCBI:1869