2. Gene
  3. MAP3K10 - mitogen-activated protein kinase kinase kinase 10 Gene

MAP3K10 - mitogen-activated protein kinase kinase kinase 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MST; MLK2; MEKK10

Gene ID: 4294 | Gene type: protein coding

About MAP3K10

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,191,426-40,215,575 (from NCBI)

This gene has 8 transcripts (splice variants), 186 orthologues and 23 paralogues. Broad expression in brain (RPKM 11.1), testis (RPKM 4.1) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal Apoptosis. [provided by RefSeq, Jul 2008]

MAP3K10 Products(1)

mRNA Protein Name
NM_002446.4 NP_002437.2 mitogen-activated protein kinase kinase kinase 10

MAP3K10 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (23 - 77)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (98 - 357)

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  • 954 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 10

MKN28 derived nonreceptor_type serine/threonine kinase

Related Diseases

Diseases Alias
Cardiofaciocutaneous Syndrome 1

Cardiofaciocutaneous Syndrome

Cfc Syndrome

Cardio-Facio-Cutaneous Syndrome

CFC1

Cfcs

Cardio-Facial-Cutaneous Syndrome

Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure

Cardiofaciocutaneous Syndrome, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08047 MAP3K10 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MAP3K10 VGNC VGNC:68154
Mus musculus MAP3K10 MGD MGI:1346879
Macaca mulatta MAP3K10 VGNC VGNC:74492
Bos taurus MAP3K10 VGNC VGNC:57052
Rattus norvegicus MAP3K10 RGD RGD:1308381
Canis familiaris MAP3K10 VGNC VGNC:53748