MMP10 - matrix metallopeptidase 10 Gene
Also Known as SL-2; STMY2
Species: Homo sapiens
About MMP10
This gene has 2 transcripts (splice variants), 516 orthologues and 23 paralogues. Restricted expression toward endometrium (RPKM 266.6).
Summary
This gene encodes a member of the peptidase M10 family of Matrix Metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of Collagen. The gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]
MMP10 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_002425.3 | NP_002416.1 | stromelysin-2 preproprotein |
MMP10 Protein Structure
PG_binding_1: Putative peptidoglycan binding domain (33 - 86)
Peptidase_M10: Matrixin (107 - 263)
Hemopexin: Hemopexin (295 - 337)
Hemopexin: Hemopexin (339 - 382)
Hemopexin: Hemopexin (387 - 433)
Hemopexin: Hemopexin (436 - 476)
- 0
- 100
- 200
- 300
- 400
- 476 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
stromelysin-2 |
|
|
Recombinant MMP10 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P700571 | MMP-10 Protein, Human (P. pastoris, His) | P09238 (F99-C476) | ≥ 90%, as determined by reducing SDS-PAGE. |
MMP10 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P811071 | MMP10 Antibody | WB, IHC-P, ICC/IF, FC | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Ophthalmomyiasis |
|
|
| Middle Cerebral Artery Infarction |
|
|
| Squamous Cell Carcinoma |
|
|
| Skin Carcinoma |
|
|
| Pyoderma Gangrenosum |
|
|
| Arthritis |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Epidermolysis Bullosa Dystrophica |
|
|
| Pyoderma |
|
|
| Gingival Overgrowth |
|
|
| Keratoconus |
|
|
Related Agents
- Approval
- Pre-clinical Phase
Approval
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-50896 | Erlotinib | 99.99% | Yes | |
| HY-12008 | Erlotinib Hydrochloride | 99.94% | Yes | |
| HY-50896R | Erlotinib (Standard) | 99.97% | Unkown | |
| HY-12008R | Erlotinib Hydrochloride (Standard) | 99.73% | Unkown | |
| HY-12008A | Erlotinib mesylate | / | Unkown |
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-P2185A | NFF-3 TFA | Chemical | 96.32% | Unkown |
| HY-161285 | MMP-9/10-IN-2 | Inhibitor | 99.87% | Unkown |
| HY-50896S | Erlotinib-d6 | 99.84% | Unkown | |
| HY-12008S | Erlotinib-d6 hydrochloride | 98.13% | Unkown | |
| HY-12008S1 | Erlotinib-13C6 hydrochloride | / | Unkown | |
| HY-50896S1 | Erlotinib-13C6 | / | Unkown | |
| HY-P2185 | NFF-3 | Chemical | / | Unkown |
| HY-RS08518 | MMP10 Human Pre-designed siRNA Set A | / | Unkown | |
| HY-RS08519 | Mmp10 Mouse Pre-designed siRNA Set A | / | Unkown | |
| HY-RS08520 | Mmp10 Rat Pre-designed siRNA Set A | / | Unkown | |
| HY-117464 | CM-352 | Inhibitor | / | Unkown |
| HY-50896S2 | Erlotinib-d4 | / | Unkown | |
| HY-50896S3 | Erlotinib-d8 | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | MMP10 | VGNC | VGNC:82014 |
| Rattus norvegicus | MMP10 | RGD | RGD:620192 |
| Macaca mulatta | MMP10 | VGNC | VGNC:74888 |
| Mus musculus | MMP10 | MGD | MGI:97007 |
| Others | MMP10 | NCBI |
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