MMP10 - matrix metallopeptidase 10 Gene

Homo sapiens

Also known as SL-2; STMY2

Gene ID: 4319 | Gene type: protein coding

About MMP10

Cytogenetic location: 11q22.2 Genomic coordinates (GRCh38): 11:102,770,502-102,780,628 (from NCBI)

This gene has 2 transcripts (splice variants), 516 orthologues and 23 paralogues. Restricted expression toward endometrium (RPKM 266.6).

Summary

This gene encodes a member of the peptidase M10 family of Matrix Metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]

MMP10 Products(1)

mRNA	Protein	Name
NM_002425.3	NP_002416.1	stromelysin-2 preproprotein

MMP10 Protein Structure

PG_binding_1

Peptidase_M10

Hemopexin

0
100
200
300
400
476 a.a.

Protein Preferred Names

Protein Names

stromelysin-2

MMP-10	matrix metalloprotease 10
matrix metalloproteinase 10 (stromelysin 2)	matrix metalloproteinase-10
transin 2

Recombinant MMP10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700571	MMP-10 Protein, Human (P. pastoris, His)	P09238 (F99-C476)	≥95%

Related Diseases

Diseases

Alias

Ophthalmomyiasis

Ocular Myiasis	Ophthalmic Myiasis
Myiasis Oestruosa

Middle Cerebral Artery Infarction

Infarction, Middle Cerebral Artery

Infarction Middle Cerebral Artery

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Malignant Squamous Cell Tumor
Squamous Carcinoma	Squamous Cell Epithelioma
Squamous Cell Skin Cancer	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Skin Carcinoma

Skin Cancer	Carcinoma Of Skin
Ca - Skin Cancer	Cancer Of Skin
Malignant Neoplasm Of Skin	Melanoma And Non-Melanoma Skin Cancer
Skin Cancers	Cancer, Skin

Pyoderma Gangrenosum

Phagedenic Pyoderma

Phagedena Geometric

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Head And Neck Cancer
Squamous Cell Carcinoma Of Lip	Squamous Cell Carcinoma, Head And Neck, Somatic
Carcinoma Of The Head And Neck	Squamous Cell Carcinomas Of Head And Neck
Scchn	Squamous Cell Carcinoma Of The Hypopharynx
Squamous Cell Carcinoma Of The Oropharynx	Squamous Cell Carcinoma Of Salivary Glands
Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses	Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses
Squamous Cell Carcinoma Of The Oral Cavity	Squamous Cell Carcinoma Of The Lip
Carcinoma, Squamous Cell Of Head And Neck	Lip Squamous Cell Carcinoma
Cancer, Head/Neck	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

Epidermolysis Bullosa Dystrophica

Dystrophic Epidermolysis Bullosa	Deb
Dermolytic Epidermolysis Bullosa	Epidermolysis Bullosa, Dermolytic
Epidermolysis Bullosa, Dystrophic	Epidermolysis Bullosa Dystrophic
Dystrophic Eb - [Epidermolysis Bullosa]

Pyoderma

Gingival Overgrowth

Gingival Enlargement	Gingival Hyperplasia
Gingival Bulge	Gingival Enlargement Nos
Gingival Hypertrophy	Gum Hypertrophy
Hyperplasia Gum	Gingival Thickening
Hyperplasia Of Gingiva	Hypertrophy Of Gingiva
Hypertrophy Of Mucous Membrane Of Gums

Keratoconus

Kc	Conical Cornea
Noninflammatory Corneal Thining	Bulging Cornea
Cornea Conical	Acquired Conus Of Cornea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2185A	NFF-3 TFA	Chemical	98.57%	Unkown
HY-161285	MMP-9/10-IN-2	Inhibitor	/	Unkown
HY-P2185	NFF-3	Chemical	/	Unkown
HY-RS08518	MMP10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08519	Mmp10 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08520	Mmp10 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MMP10	VGNC	VGNC:82014
Rattus norvegicus	MMP10	RGD	RGD:620192
Macaca mulatta	MMP10	VGNC	VGNC:74888
Mus musculus	MMP10	MGD	MGI:97007
Others	MMP10	NCBI

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