1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
    Autophagy
  2. EGFR
    Autophagy
  3. Erlotinib-13C6

Erlotinib-13C6 (Synonyms: CP-358774-13C6; NSC 718781-13C6; OSI-774-13C6)

Cat. No.: HY-50896S1
Handling Instructions

Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR.

For research use only. We do not sell to patients.

Erlotinib-13C6 Chemical Structure

Erlotinib-13C6 Chemical Structure

CAS No. : 1211107-68-4

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Description

Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].

In Vitro

Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

399.39

Formula

C1613C6H23N3O4

CAS No.
SMILES

COCCOC(C(OCCOC)=C1)=CC2=C1C(N[13C]3=[13CH][13C](C#C)=[13CH][13CH]=[13CH]3)=NC=N2

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Erlotinib-13C6
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