MT1E - metallothionein 1E Gene

Also Known as MT1; MTD; MT-1E; MT-IE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4493

About MT1E

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,625,781-56,627,112 (from NCBI)

This gene has 3 transcripts (splice variants), 186 orthologues and 11 paralogues. Broad expression in liver (RPKM 106.4), small intestine (RPKM 103.9) and 20 other tissues.

Summary

Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MT1E Products (2)

mRNA Protein Name
NM_001363555.2 NP_001350484.1 metallothionein-1E isoform 1
NM_175617.4 NP_783316.2 metallothionein-1E isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to cadmium ion IEP
IEP: Inferred from expression pattern
16827180 GOA
involved in cellular response to zinc ion IEP
IEP: Inferred from expression pattern
8119276 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
8619255 GOA
located in nucleus IDA
IDA: Inferred from direct assay
8619255 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MT1E Protein Structure

Metallothio

Metallothio: Metallothionein (1 - 61)

  • 0
  • 61 a.a.
Protein Preferred Names Protein Names

metallothionein-1E

  • metallothionein 1E (functional)

MT1E Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MT1E P04732 CCDC57 Homo sapiens Q2TAC2-2
Y2H Prey Pooling
32296183
Intra
MT1E P04732 CCDC57 Homo sapiens Q2TAC2-2
Y2H Array
32296183
Intra
MT1E P04732 CCDC57 Homo sapiens Q2TAC2-2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Frontometaphyseal Dysplasia 1

  • FMD1

  • Fmd
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Deficiency Anemia

  • Anemia

  • Deficiency Anemias

  • Anaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08737 MT1E Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MT1E MGD MGI:97171