NKTR - natural killer cell triggering receptor Gene

Also Known as p104

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4820

About NKTR

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:42,600,612-42,648,735 (from NCBI)

This gene has 18 transcripts (splice variants), 201 orthologues and 22 paralogues. Ubiquitous expression in bone marrow (RPKM 22.3), skin (RPKM 14.4) and 25 other tissues.

Summary

This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008]

NKTR Products (4)

mRNA Protein Name
NM_001349124.2 NP_001336053.1 NK-tumor recognition protein isoform c
NM_001349125.2 NP_001336054.1 NK-tumor recognition protein isoform d
NM_001349126.2 NP_001336055.1 NK-tumor recognition protein isoform e
NM_005385.4 NP_005376.2 NK-tumor recognition protein isoform a
Molecular Function GO Annotation Evidence References Source
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: Inferred from direct assay
20676357 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NKTR Protein Structure

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (11 - 175)

  • 0
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  • 1200
  • 1462 a.a.
Protein Preferred Names Protein Names

NK-tumor recognition protein

  • NK-TR protein

Related Diseases

Diseases Alias
Theileriasis
  • Theileriosis

  • Infection By Theileria

Opioid Abuse
  • Opioid-Related Disorders

Noonan Syndrome 1
  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus NKTR VGNC VGNC:32097
Macaca mulatta NKTR VGNC VGNC:81486
Rattus norvegicus NKTR RGD RGD:2321593
Felis catus NKTR VGNC VGNC:97529
Canis familiaris NKTR VGNC VGNC:56102
Mus musculus NKTR MGD MGI:97346
Others NKTR NCBI