BACE1 - beta-secretase 1 Gene

Also Known as ASP2

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 489390

About BACE1

Primary_assembly 5: 16,239,793-16,264,160 forward strand.ROS_Cfam_1.0:CM025104.1

This gene has 4 transcripts (splice variants), 220 orthologues and 10 paralogues.

BACE1 Products (1)

mRNA Protein Name
NM_001284472.1 NP_001271401.1 beta-secretase 1 precursor

BACE1 Protein Structure

beta_secretase_like

beta_secretase_like: cd05473 (71 - 436)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
Protein Preferred Names Protein Names

beta-secretase 1

  • aspartyl protease 2

  • beta-site APP-cleaving enzyme 1

  • beta-site amyloid precursor protein cleaving enzyme 1

  • membrane-associated aspartic protease 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-16759 Verubecestat Inhibitor 99.56% Phase 3
HY-100740 Lanabecestat Inhibitor 99.87% Phase 3
HY-109055 Elenbecestat Inhibitor 99.82% Phase 3
HY-13240 LY2886721 Inhibitor 99.72% Phase 2
HY-114245 Se-Methylselenocysteine Inhibitor 99.95% Phase 1
HY-10472 LY2811376 Inhibitor 99.64% Phase 1
HY-13438 AZD3839 free base Inhibitor 99.97% Phase 1
HY-109052 Atabecestat Inhibitor 98.97% Phase 1
HY-100182 BACE1-IN-1 Inhibitor 98.72% Phase 1

Pre-clinical Phase

Bioactive Molecules (43)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0226A Epiberberine chloride Inhibitor 98.68% Unkown
HY-15908 BCA Inhibitor 99.99% Unkown
HY-N1255 Scoulerine Inhibitor 99.99% Unkown
HY-136742 BACE2-IN-1 Inhibitor 99.4% Unkown
HY-124322 NB-360 Inhibitor 99.08% Unkown
HY-112157 PF-06751979 Inhibitor 99.57% Unkown
HY-W015515 L-Citronellol Inhibitor 99.92% Unkown
HY-111383 LX2343 Inhibitor 99.80% Unkown
HY-N2215 Aloeresin D Inhibitor 99.51% Unkown
HY-N2284 Sophoflavescenol Inhibitor 98.78% Unkown
HY-100740C (1α,1'S,4β)-Lanabecestat Inhibitor 96.01% Unkown
HY-N0226 Epiberberine Inhibitor 98.46% Unkown
HY-112444 BACE1-IN-2 Inhibitor / Unkown
HY-128594 BACE1-IN-4 Inhibitor / Unkown
HY-130244 BACE1-IN-5 Inhibitor / Unkown
HY-128774 AM-6494 Inhibitor / Unkown
HY-161359 BACE1-IN-14 Inhibitor / Unkown
HY-11014 NB-216 Inhibitor / Unkown
HY-P3426 BACE1-IN-10 Inhibitor / Unkown
HY-170938 AChE-IN-82 Inhibitor / Unkown
HY-N1255A Scoulerine hydrochloride Inhibitor / Unkown
HY-N13064 2,2′,4,4′-Tetrahydroxychalcone Inhibitor / Unkown
HY-182429 NB-533 Inhibitor / Unkown
HY-114234A TAK-070 Free base Inhibitor / Unkown
HY-12938 AMG-8718 Inhibitor / Unkown
HY-164956 TB-9 Inhibitor / Unkown
HY-182786 MAO-B-IN-56 Inhibitor / Unkown
HY-114234 TAK-070 hydrochloride hydrate Inhibitor / Unkown
HY-175661 SRI-22136 Inhibitor / Unkown
HY-183796 GFAP/NF-κB/APOE/NLRP3-IN-1 Inhibitor / Unkown
HY-144741 BACE1-IN-9 Inhibitor / Unkown
HY-P2713 OM99-2 Inhibitor / Unkown
HY-181160 JNK3/Wnt/β-catenin modulator-1 Inhibitor / Unkown
HY-139720 β-Secretase Inhibitor III Inhibitor / Unkown
HY-151260 AChE/BACE1/GSK3β-IN-1 Inhibitor / Unkown
HY-W750970 2-Acetoxyacorenone Inhibitor / Unkown
HY-147758 BACE1/2-IN-1 Inhibitor / Unkown
HY-122080 Memoquin Inhibitor / Unkown
HY-151348 BACE1-IN-11 Inhibitor / Unkown
HY-N18261 8-Geranyloxy-5-methoxypsoralen Inhibitor / Unkown
HY-149211 AChE/BChE-IN-12 Inhibitor / Unkown
HY-164958 TB-11 Inhibitor 98.71% Unkown
HY-126047 (S)-(-)-Anatabine Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens BACE1 NCBI NCBI:23621