BACE1 - beta-secretase 1 Gene

Also Known as ASP2; BACE; HSPC104

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23621

About BACE1

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:117,285,698-117,316,256 (from NCBI)

This gene has 18 transcripts (splice variants), 219 orthologues and 9 paralogues. Ubiquitous expression in pancreas (RPKM 33.5), brain (RPKM 30.2) and 24 other tissues.

Summary

This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]

BACE1 Products (8)

mRNA	Protein	Name
NM_138971.4	NP_620427.1	beta-secretase 1 isoform C precursor
NM_138973.4	NP_620429.1	beta-secretase 1 isoform D precursor
XM_047426686.1	XP_047282642.1	beta-secretase 1 isoform X1
NM_138972.4	NP_620428.1	beta-secretase 1 isoform B precursor
NM_012104.6	NP_036236.1	beta-secretase 1 isoform A preproprotein
NM_001207049.3	NP_001193978.1	beta-secretase 1 isoform F
NM_001411039.1	NP_001397968.1	beta-secretase 1 isoform G
NM_001207048.3	NP_001193977.1	beta-secretase 1 isoform E

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	16407538	GOA
enables aspartic-type endopeptidase activity	IDA IDA: Inferred from direct assay	10531052	GOA
enables endopeptidase activity	IDA IDA: Inferred from direct assay	10677483	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	12586838	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	8562317	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10677483	GOA
enables protein serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	24305806	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in amyloid-beta formation	IDA IDA: Inferred from direct assay	24352696	GOA
involved in amyloid-beta metabolic process	IDA IDA: Inferred from direct assay	10677483	GOA
involved in membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	18353773	GOA
involved in positive regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	29371969	GOA
involved in protein processing	IDA IDA: Inferred from direct assay	10531052	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	10531052	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	10531052	GOA
located in cell surface	IDA IDA: Inferred from direct assay	15886016	GOA
located in early endosome	IDA IDA: Inferred from direct assay	15886016	GOA
located in endosome	IDA IDA: Inferred from direct assay	10531052	GOA
located in late endosome	IDA IDA: Inferred from direct assay	16033761	GOA
located in lysosome	IDA IDA: Inferred from direct assay	16033761	GOA
located in multivesicular body	IDA IDA: Inferred from direct assay	24612608	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12586838	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	15886016	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	11466313	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BACE1 Protein Structure

Asp

0
100
200
300
400
501 a.a.

Protein Preferred Names	Protein Names
beta-secretase 1	APP beta-secretase asp 2 aspartyl protease 2 beta-site APP cleaving enzyme 1 beta-site APP-cleaving enzyme beta-site amyloid beta A4 precursor protein-cleaving enzyme memapsin-2 membrane-associated aspartic protease 2 transmembrane aspartic proteinase Asp2

BACE1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	BACE1	P56817	Clec4g	Mus musculus	Q8BNX1	Anti Bait CoIP	25957769
Cross	BACE1	P56817	Clec4g	Mus musculus	Q8BNX1	Anti Tag CoIP	25957769
Intra	BACE1	P56817	KCNC4	Homo sapiens	Q03721	Anti Bait CoIP	29507146
Intra	BACE1	P56817	KCNC4	Homo sapiens	Q03721	FRAP	29507146
Intra	BACE1	P56817	GGA1	Homo sapiens	Q9UJY5	Confocal	15466887
Intra	BACE1	P56817	GGA1	Homo sapiens	Q9UJY5	FRET	15466887
Intra	BACE1	P56817	APP	Homo sapiens	P05067	Cleavage	22801501
Intra	BACE1	P56817	APP	Homo sapiens	P05067	FRET	30538620
Intra	BACE1	P56817	APP	Homo sapiens	P05067	Confocal	10677483
Intra	BACE1	P56817	APP	Homo sapiens	P05067	Protease Assay	10677483
Intra	BACE1	P56817	IAPP	Homo sapiens	P10997	Aggregation	26840340
Intra	BACE1	P56817	SNX6	Homo sapiens	Q9UNH7	Crosslink	20354142

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BACE1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72840	BACE1 Protein, Human (HEK293)	P56817-1/NP_036236.1 (T22-T457)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72842	BACE1 Protein, Human (HEK293, His)	NP_036236.1 (T22-T457)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77569	BACE1 Protein, Human (HEK293, Fc)	P56817-1 (T22-T457)	≥ 95%, as determined by Bis-Tris PAGE.

BACE1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82169	BACE Antibody (YA1914)	WB, IP	Human, Mouse, Rat
HY-P85420	BACE Antibody (YA5112)	WB	Human, Rat, Bovine, Dog, Pig
HY-P86180	BACE Antibody (YA5872)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Inclusion Body Myositis	Ibm Sporadic Inclusion Body Myositis Myositis, Inclusion Body Inflammatory Myopathy Inflammatory Myopathies Sibm Myositis Inclusion Body Nonaka Myopathy Inclusion Body Myopathy, Autosomal Recessive Inclusion Body Myopathy, Autosomal Dominant Myositis Inclusion Body Myopathy, Sporadic
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Pick Disease Of Brain	Pick Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Pick'S Disease Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Neurosyphilis	Syphilis Of Central Nervous System Late Syphilis Of Central Nervous System Nos Late Syphilis Of The Central Nervous System Gumma Of Central Nervous System Neurosyphilis Gumma Neurosyphilitic Gumma Syphilis Of Central Nervous System Nos Syphilitic Gumma Of Central Nervous System Tertiary Central Nervous System Syphilis
Creutzfeldt-Jakob Disease	Variant Creutzfeldt-Jakob Disease CJD Bovine Spongiform Encephalopathy Vcjd Inherited Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Familial Creutzfeldt Jakob Disease Creutzfeldt-Jacob Disease Creutzfeldt Jacob Disease Sporadic Creutzfeldt-Jakob Disease Encephalopathy, Bovine Spongiform Creutzfeldt-Jakob Disease, Variant, Resistance To Creutzfeldt-Jakob Disease, Variant Creutzfeldt Jacob Syndrome Jakob-Creutzfeldt Disease Subacute Spongiform Encephalopathy Transmissible Virus Dementia New Variant Of Cjd Nv-Cjd Variant Cjd Variant Creutzfeldt-Jacob Disease Sporadic Cjd Inherited Cjd Acquired Creutzfeldt-Jakob Disease Variant Mcj Encephalopathy Bovine Spongiform Familial Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Syndrome New Variant Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Sporadic Acquired Cjd Scjd - [Sporadic Creutzfeldt-Jakob Disease] Idiopathic Creutzfeldt-Jakob Disease Creutzfeld-Jakob Disease Nos Vcjd - [Variant Creutzfeldt-Jakob Disease]
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Disease Of Mental Health	Mental Health Mental Disorders
Polyradiculoneuropathy
Alzheimer Disease 4	AD4 Alzheimer Disease-4 Alzheimer'S Disease 4 Alzheimer Disease, Familial, 4 Alzheimer Disease, Familial4 Alzheimer'S Disease 4, Early Onset Alzheimer Disease, Type 4
Subjective Cognitive Decline
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Cerebral Amyloid Angiopathy, App-Related	Hchwad Amyloidosis, Cerebroarterial, App-Related Amyloidosis, Hereditary, With Cerebral Hemorrhage, Dutch Variant Cerebral Amyloid Angiopathy, App-Related, Dutch Variant Cerebral Amyloid Angiopathy, App-Related, Iowa Variant Cerebral Amyloid Angiopathy, App-Related, Italian Variant Cerebral Amyloid Angiopathy, App-Related, Flemish Variant Cerebral Amyloid Angiopathy, App-Related, Arctic Variant Cerebral Amyloid Angiopathy, Dutch, Italian, Iowa, Flemish, Arctic Variants App-Related Cerebral Amyloid Angiopathy Abetaa21g Amyloidosis Abeta Amyloidosis, Italian Type Abeta Amyloidosis, Arctic Type Abeta Amyloidosis, Iowa Type Abeta Amyloidosis, Dutch Type Hchwa-D Abeta Amyloidosis, Flemish Type Abetaa21g-Related Amyloidosis Hchwa, Flemish Type Hereditary Cerebral Hemorrhage With Amyloidosis, Flemish Type Abetae22k Amyloidosis Hchwa, Italian Type Hereditary Cerebral Hemorrhage With Amyloidosis, Italian Type Abetae22g Amyloidosis Hchwa, Arctic Type Hereditary Cerebral Hemorrhage With Amyloidosis, Arctic Type Abetad23n Amyloidosis Hchwa, Iowa Type Hereditary Cerebral Hemorrhage With Amyloidosis, Iowa Type Abetal34v Amyloidosis Abeta Amyloidosis, Piedmont Type Abetal34v-Related Amyloidosis Hchwa, Piedmont Type Hereditary Cerebral Hemorrhage With Amyloidosis, Piedmont Type Abetae22q Amyloidosis Hchwa, Dutch Type Hereditary Cerebral Hemorrhage With Amyloidosis, Dutch Type CAA-APP Amyloidosis Cerebroarterial App-Related Amyloidosis Hereditary With Cerebral Hemorrhage Dutch Variant Cerebral Amyloid Angiopathy App-Related Arctic Variant Cerebral Amyloid Angiopathy App-Related Dutch Variant Cerebral Amyloid Angiopathy App-Related Flemish Variant Cerebral Amyloid Angiopathy App-Related Iowa Variant Cerebral Amyloid Angiopathy App-Related Italian Variant Familial Occipital Calcifications With Hemorrhagic Strokes Leukoencephalopathy Arterial Dysplasia Dementia Fochs-Ladd Hereditary Cerebral Amyloid Angiopathy Dutch Type Hereditary Cerebral Hemorrhage With Amyloidosis Dutch Type Hereditary Cerebral Hemorrhage With Amyloidosis Italian Type Cerebral Hemorrhage With Amyloidosis, Hereditary, Dutch Type
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Toxic Encephalopathy	Neurotoxicity Neurotoxicity Syndromes Neurotoxicity Syndrome Encephalopathy, Toxic
Mild Cognitive Impairment
Myositis	Idiopathic Inflammatory Myopathy Idiopathic Inflammatory Myositis Iim Imm Idiopathic Inflammatory Myopathies Myopathy, Familial Idiopathic Inflammatory Inflammatory Disorder Of Muscle Idiopathic Inflammatory Myopathy, Familial Inflammatory Myopathy, Idiopathic Myopathies Idiopathic Inflammatory Familial Idiopathic Inflammatory Myopathy
Chromosomal Duplication Syndrome
Necatoriasis	Miner'S Anaemia Negro Cachexia Dochmiasis Ground Itch Disease Brickmaker'S Chlorosis Coolie Itch Anaemia Cachexia Aquosa Dew Itch Anaemia Brickmaker'S Anaemia Tunnel Worker'S Anaemia Egyptian Anaemia Tunnel Worker'S Disease Miner'S Cachexia Greisinger Disease Tropical Chlorosis Egyptian Chlorosis Tunnel Anaemia Dochmiosis Necatorosis African Cachexia Water Itch Anaemia Infection Due To Necator Americanus St Gotthard Disease Gotthard Tunnel Disease
Normal Pressure Hydrocephalus	Low Pressure Hydrocephalus Hydrocephalus Normal Pressure Hydrocephalus, Normal Pressure Normal Pressure Hydrocephalus Nos Nph - [Normal Pressure Hydrocephalus] Normal Pressure Hydrocephaly
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Vascular Dementia	Dementia, Vascular Multi Infarct Dementia Multifocal Dementia Dementia Vascular Vascular Dementia, Susceptibility To Dementia, Multi-Infarct Multi-Infarct Dementia
Chromosomal Disease	Chromosomal Disorders Congenital Chromosomal Disease
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Alzheimer Disease 10	Ad10 Alzheimer Disease-10 Alzheimer'S Disease 10 Alzheimer Disease, Familial, 10 Alzheimer Disease Familial 10 Alzheimer'S Disease 10, Early Onset
Cerebral Amyloid Angiopathy, Cst3-Related	Cerebral Amyloid Angiopathy Hereditary Cerebral Hemorrhage With Amyloidosis Hchwa Cerebral Amyloid Angiopathy, Familial Hereditary Cystatin C Amyloid Angiopathy Amyloidosis, Cerebroarterial, Icelandic Type Amyloidosis Vi Cerebral Hemorrhage, Hereditary, With Amyloidosis Cst3-Related Cerebral Amyloid Angiopathy Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant Caa, Familial Cerebral Amyloid Angiopathy, Genetic Acys Amyloidosis Cst3-Related Amyloidosis Cystatin Amyloidosis Hchwa, Icelandic Type Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type Amyloidosis 6 AMYL6 Acys Caa Cerebral Amyloid Angiopathy Cst3-Related Cerebroarterial Amyloidosis Icelandic Type Cystatin C Amyloidosis Hccaa Hchwai Hchwa-I Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type Cerebral Amyloid Angiopathy Familial Angiopathy, Amyloid, Cerebral, Cst3-Related Hereditary Cerebral Amyloid Angiopathy, Icelandic Type Familial Cerebral Amyloid Angiopathy Cerebral Amyloid Angiopathy, Hereditary
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Alzheimer Disease 3	AD3 Alzheimer Disease, Type 3 Alzheimer Disease, Type 3, With Spastic Paraparesis And Unusual Plaques Alzheimer Disease, Type 3, With Spastic Paraparesis And Apraxia Alzheimer'S Disease 3 Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Apraxia Alzheimer Disease 3, Early-Onset Alzheimer Disease, Familial, 3 Alzheimer Disease, Protection Against, Due To Apoe3-Christchurch Alzheimer Disease 3, Early Onset Alzheimer Disease Familial 3 Early-Onset Familial Alzheimer Disease 3 Familial Alzheimer Disease 3 Familial Alzheimer Disease 3 With Spastic Paraparesis And Apraxia Familial Alzheimer Disease 3 With Spastic Paraparesis And Unusual Plaques Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Unusual Plaques Alzheimer Disease, Familial, Type 3
Amnestic Disorder	Amnesia Amnestic Syndrome Korsakoff'S Psychosis Or Syndrome Amnesic Syndrome Amnestic Disorder In Conditions Classified Elsewhere Korsakoff Psychosis Or Syndrome, Nonalcoholic Nonalcoholic Organic Amnesic Syndrome Organic Amnesic Syndrome
Cerebrovascular Disease	Cerebrovascular Accident Cerebrovascular Disorder Cerebrovascular Disorders Cva Stroke
Supranuclear Palsy, Progressive, 1	Progressive Supranuclear Palsy Steele-Richardson-Olszewski Syndrome Supranuclear Palsy, Progressive Psp Progressive Supranuclear Ophthalmoplegia PSNP1 Familial Progressive Supranuclear Palsy Richardson'S Syndrome Psp Syndrome Progressive Supranuclear Palsy 1 Supranuclear Palsy Progressive Ophthalmoplegia, Supranuclear, Progressive Steele-Richardson-Olszewksi Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16759	Verubecestat	Inhibitor	99.56%	Phase 3
HY-100740	Lanabecestat	Inhibitor	99.87%	Phase 3
HY-109055	Elenbecestat	Inhibitor	99.82%	Phase 3
HY-109052	Atabecestat	Inhibitor	98.97%	Phase 3
HY-114245	Se-Methylselenocysteine	Inhibitor	99.95%	Phase 1
HY-10472	LY2811376	Inhibitor	99.64%	Phase 1
HY-13438	AZD3839 free base	Inhibitor	99.97%	Phase 1
HY-112157	PF-06751979	Inhibitor	99.57%	Phase 1
HY-100182	BACE1-IN-1	Inhibitor	98.72%	Phase 1

Pre-clinical Phase

Bioactive Molecules (45)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13240	LY2886721	Inhibitor	99.72%	Unkown
HY-N0226A	Epiberberine chloride	Inhibitor	98.68%	Unkown
HY-15908	BCA	Inhibitor	99.99%	Unkown
HY-N1255	Scoulerine	Inhibitor	99.99%	Unkown
HY-136742	BACE2-IN-1	Inhibitor	99.4%	Unkown
HY-124322	NB-360	Inhibitor	99.08%	Unkown
HY-W015515	L-Citronellol	Inhibitor	99.92%	Unkown
HY-111383	LX2343	Inhibitor	99.80%	Unkown
HY-N2215	Aloeresin D	Inhibitor	99.51%	Unkown
HY-N2284	Sophoflavescenol	Inhibitor	98.78%	Unkown
HY-100740C	(1α,1'S,4β)-Lanabecestat	Inhibitor	96.01%	Unkown
HY-N0226	Epiberberine	Inhibitor	98.46%	Unkown
HY-128594	BACE1-IN-4	Inhibitor	/	Unkown
HY-130244	BACE1-IN-5	Inhibitor	/	Unkown
HY-128774	AM-6494	Inhibitor	/	Unkown
HY-112444	BACE1-IN-2	Inhibitor	/	Unkown
HY-170938	AChE-IN-82	Inhibitor	/	Unkown
HY-N1255A	Scoulerine hydrochloride	Inhibitor	/	Unkown
HY-181160	JNK3/Wnt/β-catenin modulator-1	Inhibitor	/	Unkown
HY-151260	AChE/BACE1/GSK3β-IN-1	Inhibitor	/	Unkown
HY-147851	BACE1-IN-12	Inhibitor	/	Unkown
HY-147758	BACE1/2-IN-1	Inhibitor	/	Unkown
HY-W750970	2-Acetoxyacorenone	Inhibitor	/	Unkown
HY-122080	Memoquin	Inhibitor	/	Unkown
HY-151348	BACE1-IN-11	Inhibitor	/	Unkown
HY-182786	MAO-B-IN-56	Inhibitor	/	Unkown
HY-149211	AChE/BChE-IN-12	Inhibitor	/	Unkown
HY-161359	BACE1-IN-14	Inhibitor	/	Unkown
HY-144741	BACE1-IN-9	Inhibitor	/	Unkown
HY-183796	GFAP/NF-κB/APOE/NLRP3-IN-1	Inhibitor	/	Unkown
HY-11014	NB-216	Inhibitor	/	Unkown
HY-P3426	BACE1-IN-10	Inhibitor	/	Unkown
HY-P2713	OM99-2	Inhibitor	/	Unkown
HY-N13064	2,2′,4,4′-Tetrahydroxychalcone	Inhibitor	/	Unkown
HY-139720	β-Secretase Inhibitor III	Inhibitor	/	Unkown
HY-182429	NB-533	Inhibitor	/	Unkown
HY-114234A	TAK-070 Free base	Inhibitor	/	Unkown
HY-12938	AMG-8718	Inhibitor	/	Unkown
HY-164956	TB-9	Inhibitor	/	Unkown
HY-N8912	Ambrosin	Inhibitor	/	Unkown
HY-114234	TAK-070 hydrochloride hydrate	Inhibitor	/	Unkown
HY-N18261	8-Geranyloxy-5-methoxypsoralen	Inhibitor	/	Unkown
HY-175661	SRI-22136	Inhibitor	/	Unkown
HY-126047	(S)-(-)-Anatabine	Inhibitor	/	Unkown
HY-164958	TB-11	Inhibitor	98.71%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BACE1	RGD	RGD:2191
Felis catus	BACE1	VGNC	VGNC:69027
Macaca mulatta	BACE1	VGNC	VGNC:70215
Mus musculus	BACE1	MGD	MGI:1346542
Bos taurus	BACE1	VGNC	VGNC:26400
Canis familiaris	BACE1	VGNC	VGNC:38358
Others	BACE1	NCBI