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Cat. No.: HY-189149

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BACE1-IN-16

BACE1-IN-16 is a BACE1 inhibitor with pIC₅₀ values ranging from 7.09 to 9.70. BACE1-IN-16 can be used for research on Alzheimer's disease.

For research use only. We do not sell to patients.

Formula: C₁₈H₁₄ClF₄N₅OS
Molecular Weight:459.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BACE1-IN-16 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

BACE1-IN-16 is a BACE1 inhibitor with pIC₅₀ values ranging from 7.09 to 9.70. BACE1-IN-16 can be used for research on Alzheimer's disease^[1].

IC₅₀ & Target

^[1]

BACE1

7.09-9.70 (pIC₅₀)

All Beta-secretase Isoforms :

BACE1
BACE2

In Vitro

BACE1-IN-16 (Compound 5) inhibits BACE1 with pIC₅₀ values ranging from 7.09 to 9.70^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 459.85
Formula C₁₈H₁₄ClF₄N₅OS
SMILES

O=C(C1=NC=C(Cl)N=C1)NC2=CC=C(F)C([C@@]3(CF)N=C(N)S[C@@]4(C(F)F)C[C@@]34[H])=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Alvarez-Ginarte Y, et al. Integrated Virtual Screening and Molecular Electrostatic Surface Potential Descriptors for Predicting BACE1 Inhibitor Interactions in Alzheimer's Disease. ACS omega. 2026 Aug 18;11(32):47739-47753. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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BACE1-IN-16

All Beta-secretase Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

BACE1-IN-16 Related Classifications

HY-189149 Related Classifications

Bioz

Keywords

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