Myb - MYB proto-oncogene, transcription factor Gene

Also Known as RGD1560020

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 498982

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and WD40-repeat domain binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of cell population proliferation; and positive regulation of Collagen biosynthetic process. Predicted to be located in cytosol and nucleoplasm. Biomarker of transient cerebral ischemia. Orthologous to human MYB (MYB proto-oncogene, transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Myb Products (2)

mRNA Protein Name
XM_039098949.1 XP_038954877.1 transcriptional activator Myb isoform X2
XM_039098940.1 XP_038954868.1 transcriptional activator Myb isoform X1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
23824072 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
8670250 RGD
involved in positive regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
15534927 RGD
involved in positive regulation of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
12599418 RGD
involved in positive regulation of hepatic stellate cell activation IMP
IMP: Inferred from mutant phenotype
10666057 RGD
involved in positive regulation of hepatic stellate cell proliferation IMP
IMP: Inferred from mutant phenotype
15534927 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
15470138 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
8665409 RGD
involved in positive regulation of testosterone secretion IMP
IMP: Inferred from mutant phenotype
15224149 RGD
involved in positive regulation of transforming growth factor beta production IMP
IMP: Inferred from mutant phenotype
15534927 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
10074303 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
24828495 RGD
involved in skeletal muscle cell proliferation IEP
IEP: Inferred from expression pattern
2447874 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcriptional activator Myb

  • v-myb avian myeloblastosis viral oncogene homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-108634 Apafant Antagonist 99.96% Phase 2
HY-141876 PRT543 / Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10238 MYBMIM Inducer 99.96% Unkown
HY-115881 SR-1114 Degrader 99.04% Unkown
HY-108634S Apafant-d8 / Unkown
HY-182681 AV-9606-129 Inhibitor / Unkown
HY-RS08869 MYB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174578 Human MYB mRNA / Unkown
HY-RS18120 Myb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24594 Myb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myb NCBI NCBI:4602