Lats2 - large tumor suppressor 2 Gene

Also Known as 4932411G09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50523

Summary

Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in G1/S transition of mitotic cell cycle; negative regulation of protein localization to nucleus; and regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including hippo signaling; inner cell mass cell differentiation; and keratinocyte differentiation. Located in spindle pole. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human LATS2 (large tumor suppressor kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Lats2 Products (2)

mRNA Protein Name
NM_015771.2 NP_056586.2 serine/threonine-protein kinase LATS2 isoform 1
NM_153382.1 NP_700431.1 serine/threonine-protein kinase LATS2 isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
15343267 MGI
acts upstream of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
21512031 MGI
acts upstream of or within hippo signaling IGI
IGI: Inferred from genetic interaction
18369314 MGI
acts upstream of or within inner cell mass cell fate commitment IGI
IGI: Inferred from genetic interaction
23824537 MGI
acts upstream of or within inner cell mass cellular morphogenesis IGI
IGI: Inferred from genetic interaction
23824537 MGI
acts upstream of or within keratinocyte differentiation IGI
IGI: Inferred from genetic interaction
18369314 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
21512031 MGI
involved in negative regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
21145499 MGI
acts upstream of or within protein localization IDA
IDA: Inferred from direct assay
19289085 MGI
acts upstream of or within protein localization IGI
IGI: Inferred from genetic interaction
19289085 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
19289085 MGI
acts upstream of or within regulation of organ growth IMP
IMP: Inferred from mutant phenotype
21512031 MGI
involved in regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21145499 MGI
Cellular Component GO Annotation Evidence References Source
located in spindle pole IDA
IDA: Inferred from direct assay
15343267 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase LATS2

  • kinase phosphorylated during mitosis protein

  • large tumor suppressor homolog 2

  • serine/threonine-protein kinase kpm

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138489 TRULI Inhibitor 99.98% Unkown
HY-147082 GA-017 98.95% Unkown
HY-W087830 L-p-Boronophenylalanine 99.84% Unkown
HY-147165 VT02956 Inhibitor 99.58% Unkown
HY-130504 Propargyl-PEG1-acid 97.0% Unkown
HY-164254 Cardiomyocyte proliferation promoting agent-1 Inhibitor 99.87% Unkown
HY-147165A VT02956 hydrochloride Inhibitor / Unkown
HY-175649 LATS1/2-IN-1 Inhibitor / Unkown
HY-RS07537 LAT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07539 LATS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18181 Lats2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21361 Lat2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24655 Lats2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27880 Lat2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lats2 NCBI NCBI:26524