Gnao1 - G protein subunit alpha o1 Gene

Also Known as Gnao; Hg1g; RATBPGTPC

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 50664

Summary

Enables several functions, including G protein-coupled receptor binding activity; GTP binding activity; and GTPase activating protein binding activity. Involved in several processes, including nervous system development; positive regulation of GTPase activity; and response to morphine. Located in membrane; myelin sheath; and neuron projection. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Orthologous to human GNAO1 (G protein subunit alpha o1). [provided by Alliance of Genome Resources, Apr 2022]

Gnao1 Products (1)

mRNA	Protein	Name
NM_017327.2	NP_059023.1	guanine nucleotide-binding protein G(o) subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled serotonin receptor binding	IPI IPI: Inferred from physical interaction	16772521	RGD
enables GTP binding	IDA IDA: Inferred from direct assay	11100733	RGD
enables GTPase activating protein binding	IPI IPI: Inferred from physical interaction	20530129	RGD
enables GTPase activity	IDA IDA: Inferred from direct assay	20530129	RGD
enables corticotropin-releasing hormone receptor 1 binding	IPI IPI: Inferred from physical interaction	20548297	RGD
enables mu-type opioid receptor binding	IPI IPI: Inferred from physical interaction	18384820	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9394004	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	9261169	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18162464	RGD
involved in forebrain development	IEP IEP: Inferred from expression pattern	8746812	RGD
involved in negative regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	7932231	RGD
involved in neuron projection development	IEP IEP: Inferred from expression pattern	7493405	RGD
involved in odontogenesis of dentin-containing tooth	IEP IEP: Inferred from expression pattern	28706494	RGD
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	7544301	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	9685638	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	11100733	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18384820	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	12199159	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in myelin sheath	IDA IDA: Inferred from direct assay	17960831	RGD
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	12837624	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	12837624	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
guanine nucleotide-binding protein G(o) subunit alpha	GTP-binding protein alpha o guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O guanine nucleotide binding protein, alpha O polypeptide 1 heterotrimeric guanine nucleotide-binding protein 1g

Gnao1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Gnao1	P59215	RGS18	Homo sapiens	Q9NS28	SPR	21685921
Cross	Gnao1	P59215	RGS18	Homo sapiens	Q9NS28	GTPase Assay	21685921
Cross	Gnao1	P59215	PRKACA	Homo sapiens	P17612	Pull Down	17148597
Cross	Gnao1	P59215	PRKACA	Homo sapiens	P17612	Anti Bait CoIP	17148597

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05538	GNAO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18822	Gnao1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25312	Gnao1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gnao1	NCBI	NCBI:2775