Slc7a5 - solute carrier family 7 member 5 Gene

Also Known as E16; TA1; LAT-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 50719

Summary

Enables amino acid transmembrane transporter activity. Involved in amino acid import across plasma membrane. Located in basolateral plasma membrane and external side of apical plasma membrane. Orthologous to human SLC7A5 (solute carrier family 7 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc7a5 Products (1)

mRNA Protein Name
NM_017353.2 NP_059049.1 large neutral amino acids transporter small subunit 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amino acid transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
28490336 RGD
Biological Process GO Annotation Evidence References Source
involved in L-amino acid transport IMP
IMP: Inferred from mutant phenotype
15980244 RGD
involved in L-leucine transport IDA
IDA: Inferred from direct assay
9726963 RGD
involved in amino acid import across plasma membrane IMP
IMP: Inferred from mutant phenotype
28490336 RGD
involved in cellular response to L-arginine IEP
IEP: Inferred from expression pattern
10681508 RGD
involved in cellular response to amino acid stimulus IEP
IEP: Inferred from expression pattern
9882595 RGD
involved in cellular response to glucose starvation IEP
IEP: Inferred from expression pattern
22185814 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
29687865 RGD
involved in isoleucine transport IDA
IDA: Inferred from direct assay
11311135 RGD
involved in isoleucine transport IMP
IMP: Inferred from mutant phenotype
25049270 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
9882595 RGD
involved in negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
25049270 RGD
involved in negative regulation of vascular associated smooth muscle cell apoptotic process IDA
IDA: Inferred from direct assay
29687865 RGD
involved in positive regulation of L-leucine import across plasma membrane IMP
IMP: Inferred from mutant phenotype
25049270 RGD
involved in positive regulation of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
16496379 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
25089378 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
24016666 RGD
involved in tryptophan transport IDA
IDA: Inferred from direct assay
12614332 RGD
involved in valine transport IMP
IMP: Inferred from mutant phenotype
25049270 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
11095508 RGD
located in basal plasma membrane IDA
IDA: Inferred from direct assay
11095508 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
18619525 RGD
located in external side of apical plasma membrane IDA
IDA: Inferred from direct assay
18619525 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
11311135 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

large neutral amino acids transporter small subunit 1

  • 4F2 LC

  • 4F2 light chain

  • 4F2LC

  • L-type amino acid transporter 1

  • TA1/LAT-1/CD98 light chain region

  • integral membrane protein E16

  • solute carrier family 7 (amino acid transporter light chain, L system), member 5

  • solute carrier family 7 (cationic amino ac

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120139 KMH-233 Inhibitor 99.75% Unkown
HY-133677 Mono(2-ethyl-5-hydroxyhexyl) phthalate 99.03% Unkown
HY-RS13331 SLC7A5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17279 Slc7a5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W267524 H-Phe(3-CF3)-OH / Unkown
HY-183513 L-Ala-BPA Substrate / Unkown
HY-158161 JN-170 Inhibitor / Unkown
HY-164401A QBS10072S dihydrochloride / Unkown
HY-RS23734 Slc7a5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W772441 H-Phe(3-tBu)-OH hydrochloride / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc7a5 NCBI NCBI:8140