Olig2 - oligodendrocyte transcription factor 2 Gene

Also Known as RK17; Olg-2; Bhlhb1; Oligo2; bHLHe19

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50913

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; HMG box domain binding activity; and identical protein binding activity. Acts upstream of or within negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; and nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; epidermis; future brain; genitourinary system; and retina. Orthologous to human OLIG2 (oligodendrocyte transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Olig2 Products (1)

mRNA Protein Name
NM_016967.2 NP_058663.2 oligodendrocyte transcription factor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14573534 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15655114 MGI
enables HMG box domain binding IPI
IPI: Inferred from physical interaction
16582099 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
15655114 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14573534 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within myelination IMP
IMP: Inferred from mutant phenotype
16436615 MGI
acts upstream of or within negative regulation of neuron differentiation IDA
IDA: Inferred from direct assay
11566099 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15655114 MGI
acts upstream of or within nervous system development IDA
IDA: Inferred from direct assay
14573534 MGI
acts upstream of neuron differentiation IDA
IDA: Inferred from direct assay
11566099 MGI
acts upstream of or within neuron fate commitment IMP
IMP: Inferred from mutant phenotype
11955448 MGI
acts upstream of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
11566099 MGI
acts upstream of or within oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
16436615 MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
11566099 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14573534 MGI
acts upstream of or within spinal cord motor neuron differentiation IMP
IMP: Inferred from mutant phenotype
21338882 MGI
acts upstream of or within spinal cord oligodendrocyte cell differentiation IGI
IGI: Inferred from genetic interaction
18287202 MGI
acts upstream of or within spinal cord oligodendrocyte cell fate specification IDA
IDA: Inferred from direct assay
18287202 MGI
acts upstream of or within thalamus development IMP
IMP: Inferred from mutant phenotype
19357274 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14573534 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14573534 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

oligodendrocyte transcription factor 2

Olig2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Olig2 Q9EQW6 Id4 Mus musculus P41139
Anti Bait CoIP
15280210
Intra
Olig2 Q9EQW6 Id4 Mus musculus P41139
Confocal
15280210
Intra
Olig2 Q9EQW6 Id4 Mus musculus P41139
Y2H
15280210
Intra
Olig2 Q9EQW6 Id4 Mus musculus P41139
Anti Tag CoIP
15280210
Intra
Olig2 Q9EQW6 Id2 Mus musculus P41136
Anti Bait CoIP
15280210
Intra
Olig2 Q9EQW6 Id2 Mus musculus P41136
Confocal
15280210
Intra
Olig2 Q9EQW6 Id2 Mus musculus P41136
Y2H
15280210
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179078 CT-179 Inhibitor 99.79% Unkown
HY-125427 SKOG102 Inhibitor 99.09% Unkown
HY-175530 OLIG2-IN-1 Inhibitor 98.55% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Olig2 NCBI NCBI:10215