COPZ2 - COPI coat complex subunit zeta 2 Gene

Also Known as zeta2-COP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51226

About COPZ2

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,026,167-48,048,053 (from NCBI)

This gene has 10 transcripts (splice variants), 192 orthologues and 1 paralogue. Broad expression in fat (RPKM 13.1), prostate (RPKM 4.4) and 22 other tissues.

Summary

This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014]

COPZ2 Products (1)

mRNA Protein Name
NM_016429.4 NP_057513.1 coatomer subunit zeta-2

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
part of COPI vesicle coat IDA
IDA: Inferred from direct assay
14729954 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPZ2 Protein Structure

Clat_adaptor_s

Clat_adaptor_s: Clathrin adaptor complex small chain (43 - 180)

  • 0
  • 100
  • 208 a.a.
Protein Preferred Names Protein Names

coatomer subunit zeta-2

  • coatomer protein complex subunit zeta 2

Related Diseases

Diseases Alias
Penis Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Penis

  • Epidermoid Cell Carcinoma Of Penis

  • Squamous Cell Carcinoma Of The Penis

  • Penile Squamous Cell Carcinoma
Intellectual Developmental Disorder, Autosomal Dominant 56

  • Mental Retardation, Autosomal Dominant 56

  • MRD56

  • Autosomal Dominant Mental Retardation 56

  • Autosomal Dominant Intellectual Developmental Disorder 56

  • Autosomal Dominant Intellectual Developmental Disorder-56
Developmental And Epileptic Encephalopathy 48

  • DEE48

  • Epileptic Encephalopathy, Early Infantile, 48

  • Eiee48

  • Developmental And Epileptic Encephalopathy, 48

  • Early Infantile Epileptic Encephalopathy 48
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03035 COPZ2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus COPZ2 VGNC VGNC:98889
Canis familiaris COPZ2 VGNC VGNC:39515
Rattus norvegicus COPZ2 RGD RGD:1306948
Macaca mulatta COPZ2 VGNC VGNC:71220
Bos taurus COPZ2 VGNC VGNC:27608
Mus musculus COPZ2 MGD MGI:1929008
Others COPZ2 NCBI