IFT25 - intraflagellar transport 25 Gene

Also Known as PP25; FAP232; HSPB11; C1orf41; CFAP232; HSPCO34

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51668

About IFT25

This gene has 6 transcripts (splice variants) and 117 orthologues. Ubiquitous expression in thyroid (RPKM 22.0), lymph node (RPKM 13.3) and 25 other tissues.

Summary

Predicted to enable metal ion binding activity. Predicted to be involved in kidney development and spermatogenesis. Predicted to act upstream of or within animal organ development; left/right axis specification; and skeletal system development. Predicted to be located in ciliary tip. Predicted to be part of intraciliary transport particle B. Predicted to be active in centrosome and cilium. [provided by Alliance of Genome Resources, Apr 2022]

IFT25 Products (9)

mRNA Protein Name
NM_001316935.2 NP_001303864.1 intraflagellar transport protein 25 homolog isoform a
NM_001382249.1 NP_001369178.1 intraflagellar transport protein 25 homolog isoform b
NM_001382250.1 NP_001369179.1 intraflagellar transport protein 25 homolog isoform b
NM_001382251.1 NP_001369180.1 intraflagellar transport protein 25 homolog isoform c
NM_001382252.1 NP_001369181.1 intraflagellar transport protein 25 homolog isoform c
NM_001382253.1 NP_001369182.1 intraflagellar transport protein 25 homolog isoform d
NM_001382254.1 NP_001369183.1 intraflagellar transport protein 25 homolog isoform e
NM_001382261.1 NP_001369190.1 intraflagellar transport protein 25 homolog isoform f
NM_016126.4 NP_057210.2 intraflagellar transport protein 25 homolog isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence References Source
part of intraciliary transport particle B IPI
IPI: Inferred from physical interaction
26980730 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intraflagellar transport protein 25 homolog

  • heat shock protein beta-11

IFT25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IFT25 Q9Y547 SEC23IP Homo sapiens Q9Y6Y8
Y2H Prey Pooling
25416956
Intra
IFT25 Q9Y547 TRAF3 Homo sapiens Q13114
Y2H Array
32296183
Intra
IFT25 Q9Y547 TRAF3 Homo sapiens Q13114
Y2H Prey Pooling
32296183
Intra
IFT25 Q9Y547 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
IFT25 Q9Y547 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra
IFT25 Q9Y547 IFT27 Homo sapiens Q9BW83
TAP
27173435
Intra
IFT25 Q9Y547 IFT27 Homo sapiens Q9BW83
Y2H Array
31515488
Intra
IFT25 Q9Y547 IFT27 Homo sapiens Q9BW83
Pull Down
27173435
Intra
IFT25 Q9Y547 IFT27 Homo sapiens Q9BW83
Y2H Array
25416956
Intra
IFT25 Q9Y547 IFT27 Homo sapiens Q9BW83
Y2H Array
32296183
Intra
IFT25 Q9Y547 IFT27 Homo sapiens Q9BW83
Anti Tag CoIP
35271311
Intra
IFT25 Q9Y547 IFT27 Homo sapiens Q9BW83
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IFT25 Proteins

Cat. No. Product Name Accession Purity
HY-P70945 HSPB11 Protein, Human (His) Q9Y547 (M1-S144) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06603 IFT25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IFT25 RGD RGD:1596413
Felis catus IFT25 VGNC VGNC:80235
Bos taurus IFT25 VGNC VGNC:55237
Macaca mulatta IFT25 VGNC VGNC:106384
Mus musculus IFT25 MGD MGI:1920188
Canis familiaris IFT25 VGNC VGNC:53414
Others IFT25 NCBI