SARAF - store-operated calcium entry associated regulatory factor Gene

Also Known as XTP3; FOAP-7; TMEM66; HSPC035

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51669

About SARAF

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:30,063,003-30,083,208 (from NCBI)

This gene has 14 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in brain (RPKM 148.3), adrenal (RPKM 121.7) and 25 other tissues.

Summary

Involved in regulation of store-operated calcium entry. Located in endoplasmic reticulum and endoplasmic reticulum-plasma membrane contact site. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

SARAF Products (2)

mRNA Protein Name
NM_001284239.1 NP_001271168.1 store-operated calcium entry-associated regulatory factor isoform 2
NM_016127.6 NP_057211.4 store-operated calcium entry-associated regulatory factor isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22464749 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of store-operated calcium entry IDA
IDA: Inferred from direct assay
22464749 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
22464749 GOA
located in endoplasmic reticulum-plasma membrane contact site IDA
IDA: Inferred from direct assay
22464749 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SARAF Protein Structure

SARAF

SARAF: SOCE-associated regulatory factor of calcium homoeostasis (20 - 339)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

store-operated calcium entry-associated regulatory factor

  • HBV X-transactivated gene 3 protein

SARAF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SARAF Q96BY9 ITCH Homo sapiens Q96J02
Anti Tag CoIP
33961781
Intra
SARAF Q96BY9 ITCH Homo sapiens Q96J02
Anti Tag CoIP
28514442
Intra
SARAF Q96BY9 STIM1 Homo sapiens Q13586
FRET
22464749
Intra
SARAF Q96BY9 STIM1 Homo sapiens Q13586
Anti Tag CoIP
22464749
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Stormorken Syndrome

  • Thrombocytopathy, Asplenia, And Miosis

  • Stormorken-Sjaastad-Langslet Syndrome

  • STRMK

  • York Platelet Syndrome

  • Yps

  • Thrombocytopathy, Asplenia And Miosis

  • Thrombocytopathy Asplenia Miosis

  • Thrombocytopathy-Asplenia-Miosis Syndrome

  • Miosis Disorder
Robinow Syndrome, Autosomal Dominant 2

  • Autosomal Dominant Robinow Syndrome 2

  • DRS2

  • Robinow, Autosomal Dominant Syndrome, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12444 SARAF Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SARAF RGD RGD:1303011
Mus musculus SARAF MGD MGI:1915137
Macaca mulatta SARAF VGNC VGNC:77118
Bos taurus SARAF VGNC VGNC:34288
Felis catus SARAF VGNC VGNC:79998
Canis familiaris SARAF VGNC VGNC:45866
Others SARAF NCBI