SARAF - store-operated calcium entry associated regulatory factor Gene

Homo sapiens

Also known as XTP3; FOAP-7; TMEM66; HSPC035

Gene ID: 51669 | Gene type: protein coding

About SARAF

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:30,063,003-30,083,208 (from NCBI)

This gene has 14 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in brain (RPKM 148.3), adrenal (RPKM 121.7) and 25 other tissues.

Summary

Involved in regulation of store-operated calcium entry. Located in endoplasmic reticulum and endoplasmic reticulum-plasma membrane contact site. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

SARAF Products(2)

mRNA	Protein	Name
NM_001284239.1	NP_001271168.1	store-operated calcium entry-associated regulatory factor isoform 2
NM_016127.6	NP_057211.4	store-operated calcium entry-associated regulatory factor isoform 1 precursor

SARAF Protein Structure

SARAF

0
100
200
300
339 a.a.

Protein Preferred Names

Protein Names

store-operated calcium entry-associated regulatory factor

HBV X-transactivated gene 3 protein

Related Diseases

Diseases

Alias

Stormorken Syndrome

Thrombocytopathy, Asplenia, And Miosis	Stormorken-Sjaastad-Langslet Syndrome
STRMK	York Platelet Syndrome
Yps	Thrombocytopathy, Asplenia And Miosis
Thrombocytopathy Asplenia Miosis	Thrombocytopathy-Asplenia-Miosis Syndrome
Miosis Disorder

Robinow Syndrome, Autosomal Dominant 2

Autosomal Dominant Robinow Syndrome 2	DRS2
Robinow, Autosomal Dominant Syndrome, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12444	SARAF Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SARAF	RGD	RGD:1303011
Mus musculus	SARAF	MGD	MGI:1915137
Macaca mulatta	SARAF	VGNC	VGNC:77118
Bos taurus	SARAF	VGNC	VGNC:34288
Felis catus	SARAF	VGNC	VGNC:79998
Canis familiaris	SARAF	VGNC	VGNC:45866

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