CMPK1 - cytidine/uridine monophosphate kinase 1 Gene

Also Known as CK; CMK; UMK; CMPK; UMPK; UMP-CMPK

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51727

About CMPK1

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:47,333,790-47,378,839 (from NCBI)

This gene has 7 transcripts (splice variants), 125 orthologues and 9 paralogues. Ubiquitous expression in colon (RPKM 74.1), duodenum (RPKM 71.2) and 25 other tissues.

Summary

This gene encodes one of the Enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]

CMPK1 Products (3)

mRNA Protein Name
NM_001136140.2 NP_001129612.1 UMP-CMP kinase isoform b
NM_001366135.1 NP_001353064.1 UMP-CMP kinase isoform c
NM_016308.3 NP_057392.1 UMP-CMP kinase isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables UMP kinase activity IDA
IDA: Inferred from direct assay
11912132 GOA
enables nucleoside diphosphate kinase activity IDA
IDA: Inferred from direct assay
23416111 GOA
enables nucleoside monophosphate kinase activity EXP
EXP: Inferred from Experiment
40615 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in UDP biosynthetic process IDA
IDA: Inferred from direct assay
11912132 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CMPK1 Protein Structure

ADK

ADK: Adenylate kinase (40 - 202)

  • 0
  • 100
  • 200
  • 228 a.a.
Protein Preferred Names Protein Names

UMP-CMP kinase

  • UMP/CMP kinase

CMPK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CMPK1 P30085 TTC19 Homo sapiens Q6DKK2
Anti Tag CoIP
33961781
Intra
CMPK1 P30085 TTC19 Homo sapiens Q6DKK2
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CMPK1 Proteins

Cat. No. Product Name Accession Purity
HY-P77273 UMP-CMP kinase/CMPK1 Protein, Human (sf9, His, solution) P30085-1 (M1-G196) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Astrakhan Spotted Fever
Nemaline Myopathy 2

  • NEM2

  • Nemaline Myopathy 2, Autosomal Recessive

  • Nemaline Myopathy, Type 2

  • Neb-Related Nemaline Myopathy

  • Myopathy, Nemaline, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02861 CMPK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20888 Cmpk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27405 Cmpk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CMPK1 RGD RGD:1310116
Bos taurus CMPK1 VGNC VGNC:27480
Mus musculus CMPK1 MGD MGI:1913838
Canis familiaris CMPK1 VGNC VGNC:39379
Felis catus CMPK1 VGNC VGNC:80170
Others CMPK1 NCBI