ATP5ME - ATP synthase membrane subunit e Gene

Also Known as ATP5I; ATP5K

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 521

Summary

Mitochondrial ATP Synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during Oxidative Phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the Other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

ATP5ME Products (1)

mRNA Protein Name
NR_033743.2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
contributes to proton-transporting ATP synthase activity, rotational mechanism IDA
IDA: Inferred from direct assay
12110673 GOA
Biological Process GO Annotation Evidence References Source
involved in proton motive force-driven mitochondrial ATP synthesis IDA
IDA: Inferred from direct assay
12110673 GOA
Cellular Component GO Annotation Evidence References Source
part of proton-transporting ATP synthase complex IDA
IDA: Inferred from direct assay
12110673 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP synthase subunit e, mitochondrial

  • ATP synthase e chain, mitochondrial

  • ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E

  • ATP synthase, H+ transporting, mitochondrial Fo complex subunit E

  • ATPase subunit e

  • F1F0-ATP synthase, murine e subunit

ATP5ME Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ATP5ME P56385 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra
ATP5ME P56385 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra
ATP5ME P56385 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra
ATP5ME P56385 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01209 ATP5MF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01210 ATP5MG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19051 Atp5mg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25541 Atp5mg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown