PFKP - phosphofructokinase, platelet Gene

Also Known as PFKF; PFK-C; PFK-P; ATP-PFK

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5214

About PFKP

Cytogenetic location: 10p15.2 Genomic coordinates (GRCh38): 10:3,067,548-3,136,805 (from NCBI)

This gene has 17 transcripts (splice variants), 296 orthologues and 2 paralogues. Broad expression in testis (RPKM 49.8), brain (RPKM 37.5) and 23 other tissues.

Summary

This gene encodes a member of the phosphofructokinase A protein family. The encoded enzyme is the platelet-specific isoform of phosphofructokinase and plays a key role in glycolysis regulation. This gene may play a role in metabolic reprogramming in some cancers, including clear cell renal cell carcinomas, and Cancer of the bladder, breast, and lung. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

PFKP Products (12)

mRNA Protein Name
NM_001242339.2 NP_001229268.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 2
NM_001323067.2 NP_001309996.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 3
NM_001323068.2 NP_001309997.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 4
NM_001323069.2 NP_001309998.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 5
NM_001323070.1 NP_001309999.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 6 precursor
NM_001323071.2 NP_001310000.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 7
NM_001323072.2 NP_001310001.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 7
NM_001323073.1 NP_001310002.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 8 precursor
NM_001323074.1 NP_001310003.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 8 precursor
NM_001345944.1 NP_001332873.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 7
NM_001410880.1 NP_001397809.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 9
NM_002627.5 NP_002618.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25985179 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
23209302 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25468996 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PFKP Protein Structure

PFK

PFK: Phosphofructokinase (25 - 335)

PFK

PFK: Phosphofructokinase (413 - 697)

  • 0
  • 200
  • 400
  • 600
  • 784 a.a.
Protein Preferred Names Protein Names

ATP-dependent 6-phosphofructokinase, platelet type

  • 6-phosphofructokinase type C

PFKP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PFKP Q01813 PFKM Homo sapiens P08237
Anti Tag CoIP
33961781
Intra
PFKP Q01813 PFKM Homo sapiens P08237
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PFKP Proteins

Cat. No. Product Name Accession Purity
HY-P75971 PFKP Protein, Human (sf9, His-GST) Q01813 (M1-V784) ≥ 90%, as determined by reducing SDS-PAGE.

PFKP Antibodies

Cat. No. Product Name Application Reactivity
HY-P81854 PFKP Antibody (YA1599) WB, ICC/IF, IP, FC Human, Mouse, Rat
HY-P81854A PFKP Antibody (YA1599)(PBS only) WB, ICC/IF, IP Human, Mouse, Rat
HY-P85892 PFKP Antibody (YA5584) WB, ICC/IF, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Glycogen Storage Disease Vii

  • Glycogen Storage Disease Type Vii

  • Muscle Phosphofructokinase Deficiency

  • Tarui Disease

  • GSD7

  • Pfkm Deficiency

  • Gsd Vii

  • Glycogen Storage Disease, Type Vii

  • Glycogen Storage Disease Type 7

  • Phosphofructokinase Deficiency

  • Glycogenosis Type Vii

  • Phosphofructokinase Myopathy

  • Glycogenosis 7

  • Glycogen Storage Disease Due To Muscle Phosphofructokinase Deficiency

  • Gsd Due To Muscle Phosphofructokinase Deficiency

  • Gsd Type 7

  • Gsd Type Vii

  • Glycogenosis Due To Muscle Phosphofructokinase Deficiency

  • Glycogenosis Type 7

  • Glycogen Storage Disease 7

  • Gsd-Vii

  • Storage Disease, Glycogen, Type Vii
Glycogen Storage Disease

  • Glycogenosis

  • Glycogenoses

  • Gsd

  • Storage Disease, Glycogen

  • Gsd - [Glycogen Storage Disease]

  • Glycogen Thesaurismosis

  • Diffuse Glycogenosis

  • Generalised Glycogen Storage Disease

  • Generalised Glycogenosis

  • Generalised Glycogen Storage Disease Of Infants

  • Glycogen Synthase Deficiency
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-124410 Mitoquinol 98.00% Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16992 Pfkp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-169061 WQQ-345 / Unkown
HY-124410S Mitoquinol-d15 Inhibitor / Unkown
HY-RS10367 PFKP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23435 Pfkp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PFKP VGNC VGNC:32775
Mus musculus PFKP MGD MGI:1891833
Macaca mulatta PFKP VGNC VGNC:84899
Rattus norvegicus PFKP RGD RGD:61893
Canis familiaris PFKP VGNC VGNC:44448
Others PFKP NCBI