PGA5 - pepsinogen A5 Gene

Homo sapiens

Also known as Pg5

Gene ID: 5222 | Gene type: protein coding

About PGA5

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,241,175-61,251,444 (from NCBI)

This gene has 6 transcripts (splice variants), 165 orthologues and 9 paralogues. Restricted expression toward stomach (RPKM 16682.6).

Summary

This gene encodes a protein precursor of the digestive Enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active Enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric Cancer. [provided by RefSeq, Jul 2015]

PGA5 Products(1)

mRNA	Protein	Name
NM_014224.5	NP_055039.1	pepsin A-5 preproprotein

PGA5 Protein Structure

A1_Propeptide

Asp

0
100
200
300
388 a.a.

Protein Preferred Names

Protein Names

pepsin A-5

Pepsin A-4

Recombinant PGA5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700144AF	Animal-Free PGA5 Protein, Human (His)	P0DJD9 (M1-A388)	≥95%

Related Diseases

Diseases

Alias

Atrophic Gastritis

Gastritis, Atrophic	Gastric Atrophy
Gastritis Atrophic

Gastritis

Acute Gastric Mucosal Erosion	Erosive Gastritis
Erosive Gastropathy	Gastritis Erosive
Idiopathic Erosive/Hemorrhagic Gastritis	Inflammation Of Gastric Mucosa
Gastroduodenitis	Gastritis Nos
Noninfectious Gastroenteritis	Nonbacterial Gastroenteritis Of Infant
Acute Gastric Infection	Acute Simple Gastritis
Chronic Antral Gastritis	Chronic Fundal Gastritis
Chronic Simple Gastritis	Acute Gastroduodenitis
Acute Antral Gastritis	Acute Erosive Gastritis
Bile Reflux Gastritis	Gastritis Due To Biliary Reflux

Barrett Esophagus

Barrett'S Esophagus	Barrett Esophagus/Esophageal Adenocarcinoma
Barrett Metaplasia	Barrett'S Ulcer Of Esophagus
Ulcerative Esophagitis	Barrett'S Esophagus With Esophagitis
Barrett'S Oesophagus	Barretts Syndrome
Barrett Syndrome	BE
Peptic Ulcer Of Esophagus	Adenocarcinoma Of Esophagus

Chief Cell Adenoma

Chief Cell Adenoma Of Parathyroid Gland

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Gastroesophageal Reflux

Gastroesophageal Reflux Disease	Gerd
GER	Gastroesophageal Reflux, Pediatric
Acid Reflux	Gastresophageal Reflux
Gastro-Esophageal Reflux	Gerd - Gastro-Esophageal Reflux Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10373	PGA5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PGA5	MGD	MGI:1915935
Rattus norvegicus	PGA5	RGD	RGD:621573