PGA5 - pepsinogen A5 Gene

Also Known as Pg5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5222

About PGA5

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,241,175-61,251,444 (from NCBI)

This gene has 6 transcripts (splice variants), 165 orthologues and 9 paralogues. Restricted expression toward stomach (RPKM 16682.6).

Summary

This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric Cancer. [provided by RefSeq, Jul 2015]

PGA5 Products (1)

mRNA Protein Name
NM_014224.5 NP_055039.1 pepsin A-5 preproprotein

PGA5 Protein Structure

A1_Propeptide

A1_Propeptide: A1 Propeptide (17 - 45)

Asp

Asp: Eukaryotic aspartyl protease (75 - 386)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

pepsin A-5

  • Pepsin A-4

Recombinant PGA5 Proteins

Cat. No. Product Name Accession Purity
HY-P700144AF Animal-Free PGA5 Protein, Human (His) P0DJD9 (M1-A388) ≥ 95%, as determined by reducing SDS-PAGE.

PGA5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84040 PGA5 Antibody (YA3737) WB, IHC-P, ELISA Human
HY-P84040A PGA5 Antibody (YA3737)(PBS only) WB, IHC-P, ELISA Human

Related Diseases

Diseases Alias
Atrophic Gastritis

  • Gastritis, Atrophic

  • Gastric Atrophy

  • Gastritis Atrophic
Gastritis

  • Acute Gastric Mucosal Erosion

  • Erosive Gastritis

  • Erosive Gastropathy

  • Gastritis Erosive

  • Idiopathic Erosive/Hemorrhagic Gastritis

  • Inflammation Of Gastric Mucosa

  • Gastroduodenitis

  • Gastritis Nos

  • Noninfectious Gastroenteritis

  • Nonbacterial Gastroenteritis Of Infant

  • Acute Gastric Infection

  • Acute Simple Gastritis

  • Chronic Antral Gastritis

  • Chronic Fundal Gastritis

  • Chronic Simple Gastritis

  • Acute Gastroduodenitis

  • Acute Antral Gastritis

  • Acute Erosive Gastritis

  • Bile Reflux Gastritis

  • Gastritis Due To Biliary Reflux
Barrett Esophagus

  • Barrett'S Esophagus

  • Barrett Esophagus/Esophageal Adenocarcinoma

  • Barrett Metaplasia

  • Barrett'S Ulcer Of Esophagus

  • Ulcerative Esophagitis

  • Barrett'S Esophagus With Esophagitis

  • Barrett'S Oesophagus

  • Barretts Syndrome

  • Barrett Syndrome

  • BE

  • Peptic Ulcer Of Esophagus

  • Adenocarcinoma Of Esophagus
Chief Cell Adenoma

  • Chief Cell Adenoma Of Parathyroid Gland
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Gastroesophageal Reflux

  • Gastroesophageal Reflux Disease

  • Gerd

  • GER

  • Gastroesophageal Reflux, Pediatric

  • Acid Reflux

  • Gastresophageal Reflux

  • Gastro-Esophageal Reflux

  • Gerd - Gastro-Esophageal Reflux Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10373 PGA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19151 Pga5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PGA5 MGD MGI:1915935
Rattus norvegicus PGA5 RGD RGD:621573