Tet1 - tet methylcytosine dioxygenase 1 Gene

Also Known as LCX; Cxxc6; mKIAA1676; D10Ertd17e; 2510010B09Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 52463

Summary

Enables methylcytosine dioxygenase activity. Involved in several processes, including dendrite morphogenesis; inner cell mass cell differentiation; and protein O-linked glycosylation. Acts upstream of or within DNA demethylation; regulation of DNA methylation; and regulation of genetic imprinting. Located in nucleus. Is expressed in several structures, including brain; early conceptus; embryo ectoderm; lower urogenital tract; and reproductive system. Orthologous to human TET1 (tet methylcytosine dioxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Tet1 Products (4)

mRNA	Protein	Name
NM_001253857.2	NP_001240786.1	methylcytosine dioxygenase TET1 isoform 1
NM_001406381.1	NP_001393310.1	methylcytosine dioxygenase TET1 isoform 3
NM_001406382.1	NP_001393311.1	methylcytosine dioxygenase TET1 isoform 5
NM_001406383.1	NP_001393312.1	methylcytosine dioxygenase TET1 isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 5-methylcytosine dioxygenase activity	IDA IDA: Inferred from direct assay	19372391	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	31467272	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21490601	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	26711116	MGI
acts upstream of or within epigenetic programing of male pronucleus	IMP IMP: Inferred from mutant phenotype	24291790	MGI
acts upstream of or within inner cell mass cell differentiation	IMP IMP: Inferred from mutant phenotype	20639862	MGI
involved in inner cell mass cell differentiation	IMP IMP: Inferred from mutant phenotype	19372391	MGI
acts upstream of or within positive regulation of gene expression via chromosomal CpG island demethylation	IDA IDA: Inferred from direct assay	20639862	MGI
involved in positive regulation of gene expression via chromosomal CpG island demethylation	IGI IGI: Inferred from genetic interaction	31467272	MGI
acts upstream of or within positive regulation of gene expression via chromosomal CpG island demethylation	IMP IMP: Inferred from mutant phenotype	21295276	MGI
involved in positive regulation of gene expression via chromosomal CpG island demethylation	IMP IMP: Inferred from mutant phenotype	19372391	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23352454	MGI
involved in protein O-linked glycosylation	IMP IMP: Inferred from mutant phenotype	23352454	MGI
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	19372391	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	19372391	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
methylcytosine dioxygenase TET1	CXXC finger 6 CXXC-type zinc finger protein 6 ten-eleven translocation 1 gene protein homolog tet oncogene 1

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W396714	Succinic acid sodium	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111558	Bobcat339	Inhibitor	99.44%	Unkown
HY-111558A	Bobcat339 hydrochloride	Inhibitor	99.62%	Unkown
HY-402410	TETi76	Inhibitor	97.49%	Unkown
HY-12303	OAC1	Activator	99.85%	Unkown
HY-122258	NSC-370284	Inhibitor	99.27%	Unkown
HY-120395	UC-514321	Inhibitor	98.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tet1	NCBI	NCBI:80312