SERPINA4 - serpin family A member 4 Gene

Homo sapiens

Also known as KAL; KST; PI4; KLST; PI-4; kallistatin

Gene ID: 5267 | Gene type: protein coding

About SERPINA4

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:94,561,442-94,569,906 (from NCBI)

This gene has 3 transcripts (splice variants), 261 orthologues and 36 paralogues. Biased expression in liver (RPKM 98.1), gall bladder (RPKM 28.7) and 2 other tissues.

Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Located in extracellular exosome. Biomarker of diabetic retinopathy. [provided by Alliance of Genome Resources, Apr 2022]

SERPINA4 Products(3)

mRNA	Protein	Name
NM_001289032.2	NP_001275961.1	kallistatin isoform 1
NM_001289033.2	NP_001275962.1	kallistatin isoform 2 precursor
NM_006215.4	NP_006206.2	kallistatin isoform 2 precursor

SERPINA4 Protein Structure

Serpin

0
100
200
300
400
427 a.a.

Protein Preferred Names

Protein Names

kallistatin

kallikrein inhibitor

Recombinant SERPINA4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71143	Serpin A4 Protein, Human (HEK293, His)	P29622 (Q21-P427)	≥95%

Related Diseases

Diseases

Alias

Cerebral Hemisphere Lipoma

Lipoma Of The Cerebral Hemisphere

Corpus Callosum Lipoma

Lipoma Of The Corpus Callosum

Lipoma Of Corpus Callosum

Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2	Acromegaly Due To Pituitary Adenoma 2
Acromegaly, X-Linked	Growth Hormone Secreting Pituitary Adenoma 2
Pituitary Adenoma, Growth Hormone-Secreting, 2	Pituitary Adenoma 2, Gh-Secreting
Gh-Secreting Pituitary Adenoma 2	X-Linked Acromegaly
Adenoma, Pituitary, Growth Hormone-Secreting, Type 2

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12700	SERPINA4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SERPINA4	VGNC	VGNC:68836
Bos taurus	SERPINA4	VGNC	VGNC:34467
Rattus norvegicus	SERPINA4	RGD	RGD:708581
Canis familiaris	SERPINA4	VGNC	VGNC:46025
Others	SERPINA4	NCBI

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