Slc40a1 - solute carrier family 40 (iron-regulated transporter), member 1 Gene

Also Known as MTP; Ol5; Pcm; Dusg; Fpn1; MTP1; IREG1; Slc11a3; Slc39a1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53945

About Slc40a1

Chromosome 1: 45,947,228-45,965,683 reverse strand.GRCm39:CM000994.3

This gene has 8 transcripts (splice variants), 211 orthologues and is associated with 65 phenotypes. Broad expression in liver E18 (RPKM 41.3), placenta adult (RPKM 28.4) and 21 other tissues.

Summary

Enables ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity. Involved in iron ion export across plasma membrane. Acts upstream of or within several processes, including multicellular organismal iron ion homeostasis; regulation of transcription by RNA polymerase II; and spleen trabecula formation. Located in basolateral plasma membrane and synaptic vesicle. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Used to study hemochromatosis type 4. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc40a1 Products (1)

mRNA Protein Name
NM_016917.2 NP_058613.2 solute carrier family 40 member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ferrous iron transmembrane transporter activity IDA
IDA: Inferred from direct assay
15514116 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
19234114 MGI
enables iron ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
10828623 MGI
enables peptide hormone binding IPI
IPI: Inferred from physical interaction
15514116 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19234114 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
15342464 MGI
acts upstream of or within endothelium development IMP
IMP: Inferred from mutant phenotype
15342464 MGI
acts upstream of or within establishment of localization in cell IGI
IGI: Inferred from genetic interaction
21700773 MGI
involved in iron ion export across plasma membrane IDA
IDA: Inferred from direct assay
15514116 MGI
acts upstream of or within iron ion transmembrane transport IGI
IGI: Inferred from genetic interaction
21700773 MGI
acts upstream of or within iron ion transport IDA
IDA: Inferred from direct assay
10828623 MGI
acts upstream of or within lymphocyte homeostasis IMP
IMP: Inferred from mutant phenotype
15888661 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
15342464 MGI
involved in multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
15084469 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15342464 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
20530874 MGI
acts upstream of or within spleen development IMP
IMP: Inferred from mutant phenotype
15342464 MGI
acts upstream of or within spleen trabecula formation IMP
IMP: Inferred from mutant phenotype
15342464 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
20530874 MGI
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IGI
IGI: Inferred from genetic interaction
19252488 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16081696 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
14972659 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc40a1 Protein Structure

FPN1

FPN1: pfam06963 (21 - 529)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 570 a.a.
Protein Preferred Names Protein Names

solute carrier family 40 member 1

  • SLC11A3 iron transporter

  • duodenal-specific

  • ferroportin 1

  • ferroportin1

  • iron-regulated transporter 1

  • metal transporter protein 1

  • metal transporting protein 1

  • polycythaemia

  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3

  • solute carrier family 39 (iron-regulated transporter), member 1

Slc40a1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Slc40a1 Q9JHI9 Slc40a1 Mus musculus Q9JHI9
Anti Tag CoIP
19234114
Intra
Slc40a1 Q9JHI9 Jak2 Mus musculus Q62120
Anti Bait CoIP
19234114
Intra
Slc40a1 Q9JHI9 Cp Mus musculus Q61147
Anti Bait CoIP
20817278
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990618 LY2928057 Inhibitor 99.9% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13243 SLC40A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13244 Slc40a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13245 SLC40A1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990510 Anti-SLC40A1 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc40a1 NCBI NCBI:30061