Rgs8 - regulator of G-protein signaling 8 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54297

About Rgs8

Primary_assembly 13: 65,804,797-65,846,807 forward strand.mRatBN7.2:CM026986.1

This gene has 3 transcripts (splice variants), 199 orthologues, 22 paralogues and is associated with 5 phenotypes. Restricted expression toward (RPKM 151.5).

Summary

Enables G-protein alpha-subunit binding activity and GTPase activator activity. Involved in several processes, including G protein-coupled acetylcholine receptor signaling pathway; positive regulation of GTPase activity; and response to amphetamine. Located in dendrite; neuronal cell body membrane; and nucleus. Is extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human RGS8 (regulator of G protein signaling 8). [provided by Alliance of Genome Resources, Apr 2022]

Rgs8 Products (1)

mRNA Protein Name
NM_019344.3 NP_062217.1 regulator of G-protein signaling 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G-protein alpha-subunit binding IPI
IPI: Inferred from physical interaction
9394004 RGD
enables GTPase activator activity IDA
IDA: Inferred from direct assay
9394004 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled acetylcholine receptor signaling pathway IDA
IDA: Inferred from direct assay
9394004 RGD
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
9394004 RGD
involved in regulation of dopamine receptor signaling pathway IDA
IDA: Inferred from direct assay
9394004 RGD
involved in response to amphetamine IEP
IEP: Inferred from expression pattern
26321241 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
12880183 RGD
located in dendrite IDA
IDA: Inferred from direct assay
12880183 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
12880183 RGD
located in nucleus IDA
IDA: Inferred from direct assay
12880183 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rgs8 Protein Structure

RGS_RGS8

RGS_RGS8: cd08711 (97 - 221)

  • 0
  • 100
  • 200
  • 232 a.a.
Protein Preferred Names Protein Names

regulator of G-protein signaling 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13509 CCG-50014 Inhibitor 99.62% Unkown
HY-U00431 CCG 203769 Inhibitor 99.76% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rgs8 NCBI NCBI:85397