2. Gene
  3. RGS8 - regulator of G protein signaling 8 Gene

RGS8 - regulator of G protein signaling 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 85397 | Gene type: protein coding

About RGS8

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:182,641,818-182,752,376 (from NCBI)

This gene has 7 transcripts (splice variants), 199 orthologues and 23 paralogues. Biased expression in thyroid (RPKM 1.7), brain (RPKM 1.0) and 3 other tissues.

Summary

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]

RGS8 Products(9)

mRNA Protein Name
NM_001387849.1 NP_001374778.1 regulator of G-protein signaling 8 isoform 2
NM_033345.4 NP_203131.1 regulator of G-protein signaling 8 isoform 1
NM_001387847.1 NP_001374776.1 regulator of G-protein signaling 8 isoform 2
NM_001369564.2 NP_001356493.1 regulator of G-protein signaling 8 isoform 2
XM_017002631.3 XP_016858120.1 regulator of G-protein signaling 8 isoform X1
NM_001102450.3 NP_001095920.1 regulator of G-protein signaling 8 isoform 2
XM_011510089.4 XP_011508391.1 regulator of G-protein signaling 8 isoform X1
XM_047432939.1 XP_047288895.1 regulator of G-protein signaling 8 isoform X2
NM_001387848.1 NP_001374777.1 regulator of G-protein signaling 8 isoform 2

RGS8 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (56 - 171)

  • 0
  • 100
  • 180 a.a.
Protein Preferred Names Protein Names

regulator of G-protein signaling 8

regulator of G-protein signalling 8

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1

SCA1

Olivopontocerebellar Atrophy I

Opca1

Opca4

Menzel Type Opca

Schut-Haymaker Type Opca

Spinocerebellar Atrophy I

Opca I

Olivopontocerebellar Atrophy Iv

Opca Iv

Cerebelloparenchymal Disorder I

Cpd1

Olivopontocerebellar Atrophy 1

Cerebelloparenchymal Disorder 1

Olivopontocerebellar Atrophy 4

Spinocerebellar Atrophy 1

Type 1 Spinocerebellar Ataxia

Spinocerebellar Ataxia-1

Ataxia, Spinocerebellar, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13509 CCG-50014 Inhibitor 99.42% Unkown
HY-U00431 CCG 203769 Inhibitor 99.76% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RGS8 MGD MGI:108408
Canis familiaris RGS8 VGNC VGNC:45538
Rattus norvegicus RGS8 RGD RGD:3571
Felis catus RGS8 VGNC VGNC:107933
Bos taurus RGS8 VGNC VGNC:33925
Macaca mulatta RGS8 VGNC VGNC:100057