RGS8 - regulator of G protein signaling 8 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85397

About RGS8

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:182,641,818-182,752,376 (from NCBI)

This gene has 7 transcripts (splice variants), 199 orthologues and 23 paralogues. Biased expression in thyroid (RPKM 1.7), brain (RPKM 1.0) and 3 other tissues.

Summary

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]

RGS8 Products (9)

mRNA Protein Name
NM_001387849.1 NP_001374778.1 regulator of G-protein signaling 8 isoform 2
NM_033345.4 NP_203131.1 regulator of G-protein signaling 8 isoform 1
NM_001387847.1 NP_001374776.1 regulator of G-protein signaling 8 isoform 2
NM_001369564.2 NP_001356493.1 regulator of G-protein signaling 8 isoform 2
XM_017002631.3 XP_016858120.1 regulator of G-protein signaling 8 isoform X1
NM_001102450.3 NP_001095920.1 regulator of G-protein signaling 8 isoform 2
XM_011510089.4 XP_011508391.1 regulator of G-protein signaling 8 isoform X1
XM_047432939.1 XP_047288895.1 regulator of G-protein signaling 8 isoform X2
NM_001387848.1 NP_001374777.1 regulator of G-protein signaling 8 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
18434541 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
18434541 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS8 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (56 - 171)

  • 0
  • 100
  • 180 a.a.
Protein Preferred Names Protein Names

regulator of G-protein signaling 8

  • regulator of G-protein signalling 8

RGS8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RGS8 P57771 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
RGS8 P57771 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 1

  • Spinocerebellar Ataxia Type 1

  • SCA1

  • Olivopontocerebellar Atrophy I

  • Opca1

  • Opca4

  • Menzel Type Opca

  • Schut-Haymaker Type Opca

  • Spinocerebellar Atrophy I

  • Opca I

  • Olivopontocerebellar Atrophy Iv

  • Opca Iv

  • Cerebelloparenchymal Disorder I

  • Cpd1

  • Olivopontocerebellar Atrophy 1

  • Cerebelloparenchymal Disorder 1

  • Olivopontocerebellar Atrophy 4

  • Spinocerebellar Atrophy 1

  • Type 1 Spinocerebellar Ataxia

  • Spinocerebellar Ataxia-1

  • Ataxia, Spinocerebellar, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13509 CCG-50014 Inhibitor 99.62% Unkown
HY-U00431 CCG 203769 Inhibitor 99.76% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RGS8 MGD MGI:108408
Canis familiaris RGS8 VGNC VGNC:45538
Rattus norvegicus RGS8 RGD RGD:3571
Felis catus RGS8 VGNC VGNC:107933
Bos taurus RGS8 VGNC VGNC:33925
Macaca mulatta RGS8 VGNC VGNC:100057
Others RGS8 NCBI