SLC12A3 - Slc12a3 solute carrier family 12 member 3 Gene

Also Known as NCC; TSC

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54300

Summary

Enables enzyme binding activity and sodium:chloride symporter activity. Involved in chloride transport and sodium ion transmembrane transport. Located in apical plasma membrane and vesicle. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Orthologous to human SLC12A3 (solute carrier family 12 member 3). [provided by Alliance of Genome Resources, Apr 2022]

SLC12A3 Products (1)

mRNA Protein Name
NM_019345.4 NP_062218.3 solute carrier family 12 member 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
11832422 RGD
enables sodium ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
16275913 RGD
enables sodium:chloride symporter activity IDA
IDA: Inferred from direct assay
10894798 RGD
enables sodium:chloride symporter activity IMP
IMP: Inferred from mutant phenotype
8021284 RGD
Biological Process GO Annotation Evidence References Source
involved in chloride transport IMP
IMP: Inferred from mutant phenotype
8021284 RGD
involved in sodium ion transmembrane transport IDA
IDA: Inferred from direct assay
16275913 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
16887815 RGD
involved in sodium ion transport IMP
IMP: Inferred from mutant phenotype
8021284 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16554416 RGD
is active in plasma membrane IDA
IDA: Inferred from direct assay
16887815 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
16275913 RGD
located in vesicle IDA
IDA: Inferred from direct assay
16554416 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

solute carrier family 12 member 3

  • Na-Cl symporter

  • solute carrier family 12 (sodium/chloride transporter), member 3

  • solute carrier family 12 (sodium/chloride transporters), member 3

  • thiazide-sensitive Na-Cl cotransporter

  • thiazide-sensitive sodium-chloride cotransporter

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B1477 Clopamide Inhibitor 99.0% Unkown
HY-RS12998 SLC12A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18580 Slc12a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25065 Slc12a3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SLC12A3 NCBI NCBI:6559