Ucp2 - uncoupling protein 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54315

Summary

Predicted to enable Oxidative Phosphorylation uncoupler activity. Involved in several processes, including cellular response to glucose stimulus; liver regeneration; and negative regulation of Insulin secretion involved in cellular response to glucose stimulus. Located in mitochondrion. Used to study hypertension; non-alcoholic fatty liver disease; transient cerebral ischemia; and type 2 diabetes mellitus. Biomarker of congestive heart failure; fatty liver disease (multiple); hypothyroidism; obstructive jaundice; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carotid artery disease; diabetic neuropathy; end stage renal disease; hypertension; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Ucp2 Products (1)

mRNA Protein Name
NM_019354.3 NP_062227.2 mitochondrial uncoupling protein 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to amino acid starvation IEP
IEP: Inferred from expression pattern
18692019 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
18692019 RGD
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
18079609 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
18079609 RGD
involved in cellular response to lead ion IEP
IEP: Inferred from expression pattern
33576715 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
19104935 RGD
involved in mitochondrial transport IDA
IDA: Inferred from direct assay
12372827 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18703058 RGD
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
21172424 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
20393169 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
18079609 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
18079609 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
17704287 RGD
involved in response to superoxide IDA
IDA: Inferred from direct assay
12372827 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial uncoupling protein 2

  • UCP 2

  • Uncoupling protein 2, mitochondrial

  • solute carrier family 25 member 8

  • uncoupling protein 2 (mitochondrial, proton carrier)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-17389 Genipin Inhibitor 99.80% Phase 3
HY-138830 TAK-418 Inhibitor 99.81% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120160 Darglitazone Agonist 99.19% Unkown
HY-101824 NC-2100 Activator / Unkown
HY-120160A Darglitazone Sodium Agonist / Unkown
HY-RS15411 UCP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17900 Ucp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24369 Ucp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ucp2 NCBI NCBI:7351