Extl3 - exostosin-like glycosyltransferase 3 Gene

Also Known as Ext1l; mKIAA0519; 2900009G18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54616

Summary

Predicted to enable Glycosyltransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process and positive regulation of cell growth. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; heart; metanephros; and sensory organ. Orthologous to human EXTL3 (exostosin like Glycosyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]

Extl3 Products (11)

mRNA Protein Name
NM_001360385.2 NP_001347314.1 exostosin-like 3 isoform 1
NM_001404938.1 NP_001391867.1 exostosin-like 3 isoform 1
NM_001404939.1 NP_001391868.1 exostosin-like 3 isoform 1
NM_001404940.1 NP_001391869.1 exostosin-like 3 isoform 1
NM_001404941.1 NP_001391870.1 exostosin-like 3 isoform 1
NM_001404942.1 NP_001391871.1 exostosin-like 3 isoform 2
NM_001404943.1 NP_001391872.1 exostosin-like 3 isoform 2
NM_001404944.1 NP_001391873.1 exostosin-like 3 isoform 3
NM_001404945.1 NP_001391874.1 exostosin-like 3 isoform 3
NM_001404946.1 NP_001391875.1 exostosin-like 3 isoform 3
NM_018788.4 NP_061258.2 exostosin-like 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-hormone receptor activity IDA
IDA: Inferred from direct assay
22727489 MGI
enables protein-hormone receptor activity IMP
IMP: Inferred from mutant phenotype
36240758 MGI
Biological Process GO Annotation Evidence References Source
involved in heparan sulfate proteoglycan biosynthetic process IMP
IMP: Inferred from mutant phenotype
19336225 MGI
involved in negative regulation of cytokine production involved in inflammatory response IDA
IDA: Inferred from direct assay
28811323 MGI
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
28811323 MGI
involved in negative regulation of inflammatory response to wounding IDA
IDA: Inferred from direct assay
27830702 MGI
involved in negative regulation of keratinocyte differentiation IDA
IDA: Inferred from direct assay
22727489 MGI
involved in positive regulation of detection of glucose IMP
IMP: Inferred from mutant phenotype
36240758 MGI
involved in positive regulation of keratinocyte proliferation IDA
IDA: Inferred from direct assay
22727489 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
22727489 MGI
involved in response to lipopolysaccharide IDA
IDA: Inferred from direct assay
35263589 MGI
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
27830702 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

exostosin-like 3

  • exostoses (multiple)-like 3

  • exostoses-like 3

  • exostosin

  • glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

  • multiple exostosis-like protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04610 EXTL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21566 Extl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28084 Extl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Extl3 NCBI NCBI:2137