SIRPG - signal regulatory protein gamma Gene

Also Known as CD172g; SIRPB2; SIRP-B2; bA77C3.1; SIRPgamma

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55423

About SIRPG

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:1,629,152-1,686,455 (from NCBI)

This gene has 7 transcripts (splice variants), 281 orthologues and 4 paralogues. Biased expression in lymph node (RPKM 13.6), appendix (RPKM 6.0) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

SIRPG Products (3)

mRNA Protein Name
NM_001039508.2 NP_001034597.1 signal-regulatory protein gamma isoform 3 precursor
NM_018556.4 NP_061026.2 signal-regulatory protein gamma isoform 1 precursor
NM_080816.3 NP_543006.2 signal-regulatory protein gamma isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15383453 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of T cell activation IDA
IDA: Inferred from direct assay
15383453 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15383453 GOA
involved in positive regulation of cell-cell adhesion IDA
IDA: Inferred from direct assay
15383453 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
15383453 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRPG Protein Structure

V-set

V-set: Immunoglobulin V-set domain (33 - 128)

C1-set

C1-set: Immunoglobulin C1-set domain (160 - 234)

C1-set

C1-set: Immunoglobulin C1-set domain (261 - 335)

  • 0
  • 100
  • 200
  • 300
  • 387 a.a.
Protein Preferred Names Protein Names

signal-regulatory protein gamma

  • CD172 antigen-like family member B

SIRPG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SIRPG Q9P1W8 CD47 Homo sapiens Q08722
FACS
15383453
Intra
SIRPG Q9P1W8 GATM Homo sapiens P50440
Y2H Array
32814053
Intra
SIRPG Q9P1W8 GATM Homo sapiens P50440
Validated Y2H
32814053
Intra
SIRPG Q9P1W8 GATM Homo sapiens P50440
Y2H Pooling
32814053
Intra
SIRPG Q9P1W8 FOS Homo sapiens P01100
Validated Y2H
32814053
Intra
SIRPG Q9P1W8 FOS Homo sapiens P01100
Y2H Array
32814053
Intra
SIRPG Q9P1W8 FOS Homo sapiens P01100
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIRPG Proteins

Cat. No. Product Name Accession Purity
HY-P71316 SIRP gamma Protein, Human (HEK293, Fc) Q9P1W8-1 (E29-P360) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78210 SIRP gamma Protein, Human (Biotinylated, HEK293, His-Avi) Q9P1W8-1 (E29-P360) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78521 SIRP gamma Protein, Human (HEK293, His-Avi) Q9P1W8-1 (E29-P360) ≥ 95%, as determined by Bis-Tris PAGE.

SIRPG Antibodies

Cat. No. Product Name Application Reactivity
HY-P84844 CD172G Antibody (YA4541) ICC/IF, FC, ELISA Human
HY-P84844A CD172G Antibody (YA4541)(PBS only) ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Hemolytic Disease Of Fetus And Newborn, Rh-Induced

  • Rh Deficiency Syndrome

  • Rh Disease

  • HDFNRH

  • Rh Fetomaternal Incompatibility

  • Rh-Null Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12936 SIRPG Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Others SIRPG NCBI