2. Gene
  3. SIRPG - signal regulatory protein gamma Gene

SIRPG - signal regulatory protein gamma Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CD172g; SIRPB2; SIRP-B2; bA77C3.1; SIRPgamma

Gene ID: 55423 | Gene type: protein coding

About SIRPG

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:1,629,152-1,686,455 (from NCBI)

This gene has 7 transcripts (splice variants), 281 orthologues and 4 paralogues. Biased expression in lymph node (RPKM 13.6), appendix (RPKM 6.0) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

SIRPG Products(3)

mRNA Protein Name
NM_001039508.2 NP_001034597.1 signal-regulatory protein gamma isoform 3 precursor
NM_018556.4 NP_061026.2 signal-regulatory protein gamma isoform 1 precursor
NM_080816.3 NP_543006.2 signal-regulatory protein gamma isoform 2 precursor

SIRPG Protein Structure

V-set

V-set: Immunoglobulin V-set domain (33 - 128)

C1-set

C1-set: Immunoglobulin C1-set domain (160 - 234)

C1-set

C1-set: Immunoglobulin C1-set domain (261 - 335)

  • 0
  • 100
  • 200
  • 300
  • 387 a.a.
Protein Preferred Names Protein Names

signal-regulatory protein gamma

CD172 antigen-like family member B

Recombinant SIRPG Proteins

Cat. No. Product Name Accession Purity
HY-P71316 SIRP gamma Protein, Human (HEK293, Fc) Q9P1W8 (E29-P360) ≥95%
HY-P78210 SIRP gamma Protein, Human (Biotinylated, HEK293, His-Avi) Q9P1W8 (E29-P360) ≥95%
HY-P78521 SIRP gamma Protein, Human (HEK293, His-Avi) Q9P1W8 (E29-P360) ≥95%

Related Diseases

Diseases Alias
Hemolytic Disease Of Fetus And Newborn, Rh-Induced

Rh Deficiency Syndrome

Rh Disease

HDFNRH

Rh Fetomaternal Incompatibility

Rh-Null Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12936 SIRPG Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca fascicularis SIRPG NCBI
Others SIRPG NCBI