PRB4 - proline rich protein BstNI subfamily 4 Gene

Also Known as Po

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5545

About PRB4

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:11,307,077-11,310,436 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 6 orthologues and 6 paralogues. Restricted expression toward salivary gland (RPKM 1203.4).

Summary

This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Small" allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]

PRB4 Products (2)

mRNA	Protein	Name
NM_001261399.3	NP_001248328.1	basic salivary proline-rich protein 4 isoform 2 preproprotein
NM_002723.6	NP_002714.2	basic salivary proline-rich protein 4 isoform 1 preproprotein

PRB4 Protein Structure

Pro-rich

0
100
200
247 a.a.

Protein Preferred Names	Protein Names
basic salivary proline-rich protein 4	BstNI type basic salivary proline-rich protein 4

Related Diseases

Diseases	Alias
Hypogonadotropic Hypogonadism 6 With Or Without Anosmia	HH6 Kallmann Syndrome 6 Kal6 Hypogonadotropic Hypogonadism, Type 6 With/Without Anosmia
Head And Neck Cancer	Head And Neck Neoplasm Head And Neck Tumours Head/Neck Neoplasm Tumor Of Head And Neck Head And Neck Neoplasms Hnc Cancer, Head/Neck
Bilateral Renal Aplasia
Hypopharynx Cancer	Hypopharyngeal Cancer Malignant Neoplasm Of Hypopharynx Hypopharyngeal Neoplasms Hypopharyngeal Carcinoma Malignant Hypopharyngeal Tumor Malignant Tumor Of Hypopharynx Malignant Tumour Of Hypopharynx
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11054	PRB4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown