Samhd1 - SAM domain and HD domain, 1 Gene

Also Known as Mg11; mSAMHD1; E330031J07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56045

Summary

Enables dGTPase activity. Involved in several processes, including dATP catabolic process; negative regulation of type I interferon-mediated signaling pathway; and protein homotetramerization. Predicted to be located in nucleoplasm; site of double-strand break; and tetraspanin-enriched microdomain. Predicted to be active in nucleus. Is expressed in left lung; right lung; and thymus primordium. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; acute myeloid leukemia; hepatitis B; and hepatitis C. Orthologous to human SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]

Samhd1 Products (3)

mRNA Protein Name
NM_001139520.2 NP_001132992.2 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform 2
NM_001370610.1 NP_001357539.1 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform 3
NM_018851.4 NP_061339.4 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables dGTPase activity IDA
IDA: Inferred from direct assay
29379009 MGI
enables triphosphoric monoester hydrolase activity IDA
IDA: Inferred from direct assay
29379009 MGI
Biological Process GO Annotation Evidence References Source
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
23972988 MGI
involved in negative regulation of type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
23972988 MGI
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
29379009 MGI
involved in somatic hypermutation of immunoglobulin genes IMP
IMP: Inferred from mutant phenotype
29669924 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

deoxynucleoside triphosphate triphosphohydrolase SAMHD1

  • IFN-gamma induced

  • SAM domain and HD domain-containing protein 1

  • dNTPase

  • interferon-gamma-inducible protein Mg11

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B1299A Cephalosporin C zinc salt Inhibitor 99.31% Unkown
HY-161296 TH6342 Inhibitor 99.15% Unkown
HY-RS12433 SAMHD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-137613 Sp-TTPαS Inhibitor / Unkown
HY-137613A Sp-TTPαS tetrasodium Inhibitor / Unkown
HY-137618A Sp-dGTPαS tetrasodium / Unkown
HY-137618B Rp-dGTPαS / Unkown
HY-137619A Sp-dCTPαS tetrasodium / Unkown
HY-182970 PROTAC SAMHD1 Degrader-1 Inhibitor / Unkown
HY-182973 SAMHD1 ligand-1 / Unkown
HY-182974 DCAF1 binder 3 / Unkown
HY-182975 E3 Ligase Ligand-linker Conjugate 229 / Unkown
HY-RS17783 Samhd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24250 Samhd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Samhd1 NCBI NCBI:25939