2. Anti-infection
  3. HIV Bacterial
  4. TH6342

TH6342 is a SAMHD1 modulator that binds to pretetrameric SAMHD1 and prevents its oligomerization and allosteric activation. SAMHD1 is a dNTP triphosphohydrolase and an HIV-1 restriction factor. SAMHD1 can limit the replication of retroviruses and DNA viruses and has antiviral effects. The inhibitory mechanism of TH6342 does not occupy the SAMHD1 nucleotide-binding pocket, gently binds the target, and functions as a chemical probe.

For research use only. We do not sell to patients.

TH6342 Chemical Structure

TH6342 Chemical Structure

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TH6342 Related Antibodies

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Description

TH6342 is a SAMHD1 modulator that binds to pretetrameric SAMHD1 and prevents its oligomerization and allosteric activation. SAMHD1 is a dNTP triphosphohydrolase and an HIV-1 restriction factor. SAMHD1 can limit the replication of retroviruses and DNA viruses and has antiviral effects. The inhibitory mechanism of TH6342 does not occupy the SAMHD1 nucleotide-binding pocket, gently binds the target, and functions as a chemical probe[1].

In Vitro

TH6342 (2.5, 10, 40 μM) blocks dGTP-induced SAMHD1 activation in a dose-dependent manne, without altering the stability of SAMHD1 to pronase treatment under 0.05-0.5 mM concentartion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TH6342 Related Antibodies
Molecular Weight

349.82

Formula

C19H16ClN5
SMILES

ClC(C=CC=C1)=C1C(N=C2NCCC3=NC=CC=C3)=CN4C2=NC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TH6342 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TH6342TH 6342TH-6342HIVBacterialHuman immunodeficiency viruschemical probeoligomerizationallosteric activationInhibitorinhibitorinhibit

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