Becn1 - beclin 1, autophagy related Gene

Also Known as Atg6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56208

About Becn1

Chromosome 11: 101,176,778-101,193,112 reverse strand.GRCm39:CM001004.3

This gene has 17 transcripts (splice variants), 214 orthologues, 1 paralogue and is associated with 43 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 39.6), bladder adult (RPKM 35.6) and 28 other tissues.

Summary

Enables identical protein binding activity. Involved in several processes, including Autophagy of mitochondrion; cellular response to glucose starvation; and engulfment of apoptotic cell. Acts upstream of or within several processes, including amyloid-beta metabolic process; negative regulation of autophagosome assembly; and positive regulation of cardiac muscle hypertrophy. Located in autophagosome; phagocytic vesicle; and trans-Golgi network. Part of phosphatidylinositol 3-kinase complex, class III. Is expressed in central nervous system; extraembryonic visceral endoderm; sensory organ; and spleen. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to human BECN1 (beclin 1). [provided by Alliance of Genome Resources, Apr 2022]

Becn1 Products (4)

mRNA Protein Name
NM_001359820.1 NP_001346749.1 beclin-1 isoform 3
NM_001359821.1 NP_001346750.1 beclin-1 isoform 4
NM_001359819.1 NP_001346748.1 beclin-1 isoform 2
NM_019584.4 NP_062530.2 beclin-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
27994061 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12372286 MGI
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
25275521 MGI
Biological Process GO Annotation Evidence Referencias Source
acts upstream of or within amyloid-beta metabolic process IMP
IMP: Inferred from mutant phenotype
18497889 MGI
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
23332761 MGI
acts upstream of or within autophagy IDA
IDA: Inferred from direct assay
12372286 MGI
involved in autophagy IDA
IDA: Inferred from direct assay
23364696 MGI
involved in cellular response to glucose starvation IDA
IDA: Inferred from direct assay
23332761 MGI
involved in engulfment of apoptotic cell IMP
IMP: Inferred from mutant phenotype
22393062 MGI
acts upstream of or within lysosome organization IMP
IMP: Inferred from mutant phenotype
18497889 MGI
acts upstream of or within macroautophagy IGI
IGI: Inferred from genetic interaction
17468177 MGI
acts upstream of or within macroautophagy IMP
IMP: Inferred from mutant phenotype
14657337 MGI
involved in macroautophagy IMP
IMP: Inferred from mutant phenotype
23332761 MGI
acts upstream of or within negative regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
27994061 MGI
acts upstream of or within negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
27994061 MGI
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
17589504 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
18497889 MGI
acts upstream of or within positive regulation of cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
27994061 MGI
acts upstream of or within regulation of catalytic activity IMP
IMP: Inferred from mutant phenotype
22493499 MGI
acts upstream of or within response to other organism IDA
IDA: Inferred from direct assay
9765397 MGI
Cellular Component GO Annotation Evidence Referencias Source
located in autophagosome IDA
IDA: Inferred from direct assay
23798385 MGI
is active in cytoplasm IDA
IDA: Inferred from direct assay
22498477 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17589504 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
12372286 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
22493499 MGI
part of phosphatidylinositol 3-kinase complex, class III IDA
IDA: Inferred from direct assay
23332761 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
17891140 MGI
located in trans-Golgi network IDA
IDA: Inferred from direct assay
12372286 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Becn1 Protein Structure

BH3

BH3: pfam15285 (102 - 126)

APG6_N

APG6_N: pfam17675 (132 - 258)

APG6

APG6: pfam04111 (264 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 448 a.a.
Protein Preferred Names Protein Names

beclin-1

  • Bcl-2-interacting protein beclin

  • Beclin-1

  • coiled-coil, myosin-like BCL2-interacting protein

Becn1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
Becn1 O88597 Nrbf2 Mus musculus Q8VCQ3
Anti Bait CoIP
24849286
Intra
Becn1 O88597 Nrbf2 Mus musculus Q8VCQ3
Anti Tag CoIP
24849286
Intra
Becn1 O88597 Gopc Mus musculus Q8BH60
IF
12372286
Intra
Becn1 O88597 Gopc Mus musculus Q8BH60
Y2H
12372286
Intra
Becn1 O88597 Gopc Mus musculus Q8BH60
Anti Tag CoIP
12372286
Intra
Becn1 O88597 Bcl2 Mus musculus P10417
Anti Bait CoIP
29849149
Intra
Becn1 O88597 Bcl2 Mus musculus P10417
Anti Bait CoIP
20819940
Intra
Becn1 O88597 Hmgb1 Mus musculus P63158
Anti Bait CoIP
20819940
Intra
Becn1 O88597 Pik3c3 Mus musculus Q6PF93
Anti Tag CoIP
24849286
Intra
Becn1 O88597 Pik3c3 Mus musculus Q6PF93
Anti Bait CoIP
23332761
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-137506 XST-14 99.26% Unkown
HY-N1956 Rubiadin-1-methyl ether Inhibitor 98.57% Unkown
HY-149954 SARS-CoV-2-IN-39 Inhibitor 99.79% Unkown
HY-RS01463 BECN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01464 Becn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01465 Becn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Becn1 NCBI NCBI:8678